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Substance Name: Deprenyl hydrochloride
RN: 2079-54-1
UNII: 63G7R4955A
InChIKey: IYETZZCWLLUHIJ-UHFFFAOYSA-N

Note

  • A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.

Molecular Formula

  • C13-H17-N.Cl-H

Molecular Weight

  • 223.7452
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Deprenyl hydrochloride

Synonyms

  • 2-Propynylamine, N-methyl-N-(alpha-methylphenethyl)-, hydrochloride
  • Deprenalin
  • Deprenaline hydrochloride
  • Deprenyl HCl
  • Deprenyl hydrochloride
  • E-250
  • N,alpha-Dimethyl-N-2-propynylphenethylamine hydrochloride
  • Phenylisopropylmethylpropinylamine hydrochloride
  • UNII-63G7R4955A

Systematic Name

  • Phenethylamine, N,alpha-dimethyl-N-2-propynyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 2079-54-1

FDA UNII

  • 63G7R4955A

Related Registry Number

  • 14611-51-9 (Parent)

System Generated Number

  • 0002079541

Molecular Formulas

Molecular Formula

  • C13-H17-N.Cl-H

Molecular Formula Fragments

  • C13-H17-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H

InChIKey

IYETZZCWLLUHIJ-UHFFFAOYSA-N

Smiles

Cl.CC(Cc1ccccc1)N(C)CC#C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 45mg/kg (45mg/kg)   Acta Biologica et Medica Germanica. Vol. 17, Pg. 614, 1966.
rat LD50 intravenous 63mg/kg (63mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 154, 1965.
rat LD50 oral 385mg/kg (385mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 154, 1965.
rat LD50 subcutaneous 126mg/kg (126mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 154, 1965.