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Substance Name: Osmium tetroxide
RN: 20816-12-0
UNII: P40W033BGM
InChIKey: VUVGYHUDAICLFK-UHFFFAOYSA-N

Note

  • (T-4)-Osmium oxide (OsO4). A highly toxic and volatile oxide of osmium used in industry as an oxidizing agent. It is also used as a histological fixative and stain and as a synovectomy agent in arthritic joints. Its vapor can cause eye, skin, and lung damage.

Molecular Formula

  • O4-Os

Molecular Weight

  • 254.226
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect

Superlist Classification Codes

  • Reportable Quantity (RQ) = 1000 lb
  • TWA (0.0002 ppm); STEL (0.0006 ppm)
  • TWA 0.002 mg/m3

Names and Synonyms

Name of Substance

  • Osmium tetroxide

MeSH Heading

  • Osmium tetroxide

Synonyms

  • EINECS 244-058-7
  • HSDB 719
  • Osmic acid
  • Osmic acid anhydride
  • Osmium tetraoxide
  • Osmium tetroxide
  • Perosmic acid anhydride
  • Perosmic oxide
  • RCRA waste number P087
  • UNII-P40W033BGM

Systematic Names

  • Osmium oxide (OsO4), (beta-4)-
  • Osmium oxide (OsO4), (T-4)-
  • Osmium tetraoxide
  • Osmium tetroxide

Superlist Names

  • Osmium oxide (OsO4) (T-4)-
  • Osmium oxide, (T-4)-
  • Osmium tetroxide
  • Osmium tetroxide [UN2471] [Poison]
  • RCRA waste no. P087
  • UN2471

Registry Numbers

CAS Registry Number

  • 20816-12-0

FDA UNII

  • P40W033BGM

Other Registry Numbers

  • 12060-19-4
  • 7446-13-1

System Generated Number

  • 0020816120

Structure Descriptors

InChI

1S/4O.Os

InChIKey

VUVGYHUDAICLFK-UHFFFAOYSA-N

Smiles

[Os](=O)(=O)(=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TCLo inhalation 133ug/m3 (0.133mg/m3) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
British Journal of Industrial Medicine. Vol. 3, Pg. 183, 1946.
mouse LCLo inhalation 40ppm/4H (40ppm)   Shell Chemical Company. Unpublished Report. Vol. -, Pg. 8, 1961.
mouse LD50 intraperitoneal 13500ug/kg (13.5mg/kg)   Shell Chemical Company. Unpublished Report. Vol. -, Pg. 8, 1961.
mouse LD50 oral 162mg/kg (162mg/kg)   Shell Chemical Company. Unpublished Report. Vol. -, Pg. 8, 1961.
rabbit LCLo inhalation 1316mg/m3/30M (1316mg/m3) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Journal of Industrial Hygiene. Vol. 15, Pg. 136, 1933.
rat LCLo inhalation 40ppm/4H (40ppm)   Shell Chemical Company. Unpublished Report. Vol. -, Pg. 8, 1961.
rat LD50 intraperitoneal 14100ug/kg (14.1mg/kg)   Shell Chemical Company. Unpublished Report. Vol. -, Pg. 8, 1961.