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Substance Name: Guanylthiourea
RN: 2114-02-5
UNII: LF1NJY8ID8
InChIKey: OKGXJRGLYVRVNE-UHFFFAOYSA-N

Note

  • May protect against hypoxic damage; proposed for treatment of shock due to trauma or blood loss; also stimulates paretic gastrointestinal system.

Molecular Formula

  • C2-H6-N4-S

Molecular Weight

  • 118.163
 
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Names and Synonyms

Name of Substance

  • Guanylthiourea

MeSH Heading

  • Guanylthiourea

Synonyms

  • 1-Amidino-2-thiourea
  • 1-Amidinothiourea
  • AI3-62541
  • Amidinothiourea
  • EC 218-308-0
  • EINECS 218-308-0
  • Guanylthiourea
  • Guthimin
  • Guthimine
  • Gutimine
  • N-Amidinothiourea
  • NSC 55743
  • Thiodicyanodiamidine
  • Thiourea, (aminoiminomethyl)-
  • UNII-LF1NJY8ID8
  • Urea, 1-guanyl-2-thio-

Systematic Names

  • 1-Amidino-2-thiourea
  • Thiourea, (aminoiminomethyl)-
  • Urea, 1-amidino-2-thio-

Registry Numbers

CAS Registry Number

  • 2114-02-5

FDA UNII

  • LF1NJY8ID8

System Generated Number

  • 0002114025

Structure Descriptors

InChI

1S/C2H6N4S/c3-1(4)6-2(5)7/h(H6,3,4,5,6,7)

InChIKey

OKGXJRGLYVRVNE-UHFFFAOYSA-N

Smiles

C(NC(N)=S)(N)=N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1440mg/kg (1440mg/kg)   Pharmaceutical Chemistry Journal Vol. 30, Pg. 181, 1996.
rat LD oral > 500mg/kg (500mg/kg)   National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 46, 1953.