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Substance Name: Oxaprozin [USAN:USP:INN:BAN:JAN]
RN: 21256-18-8
UNII: MHJ80W9LRB
InChIKey: OFPXSFXSNFPTHF-UHFFFAOYSA-N
Molecular Formula
- C18-H15-N-O3
Molecular Weight
- 293.32
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Drug / Therapeutic Agent
- Human Data
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
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Names and Synonyms
Name of Substance
- Oxaprozin
- Oxaprozin [USAN:USP:INN:BAN:JAN]
Synonyms
- 3-(4,5-Diphenyl-2-oxazolyl)propenoic acid
- 4,5-Diphenyl-2-oxazolepropanoic acid
- Alvo
- beta-(4,5-Diphenyloxazol-2-yl)propionic acid
- BRN 1083168
- Daypro
- Deflam
- EINECS 244-296-1
- HSDB 7586
- NSC 310839
- Oxaprozin
- Oxaprozina
- Oxaprozina [INN-Spanish]
- Oxaprozine
- Oxaprozine [INN-French]
- Oxaprozinum
- Oxaprozinum [INN-Latin]
- UNII-MHJ80W9LRB
- Voir
- WY-21,743
- WY-21743
Systematic Names
- 2-Oxazolepropanoic acid, 4,5-diphenyl-
- Oxaprozin
Registry Numbers
CAS Registry Number
- 21256-18-8
FDA UNII
- MHJ80W9LRB
System Generated Number
- 0021256188
Structure Descriptors
InChI
1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)InChIKey
OFPXSFXSNFPTHF-UHFFFAOYSA-NSmiles
c1(c(oc(n1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
dog | LD50 | intravenous | 124mg/kg (124mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
dog | LD50 | oral | > 2gm/kg (2000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. | |
dog | LD50 | subcutaneous | > 1gm/kg (1000mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BLOOD: HEMORRHAGE | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
man | TDLo | oral | 171mg/kg/10D- (171mg/kg) | SKIN AND APPENDAGES (SKIN): SWEATING: OTHER CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BEHAVIORAL: TOXIC PSYCHOSIS | American Journal of Psychiatry. Vol. 152, Pg. 149, 1995. |
mouse | LD50 | intraperitoneal | 376mg/kg (376mg/kg) | GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
mouse | LD50 | intravenous | 93mg/kg (93mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
mouse | LD50 | oral | 1210mg/kg (1210mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
mouse | LD50 | subcutaneous | 556mg/kg (556mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: OTHER CHANGES | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
rabbit | LD50 | intraperitoneal | 248mg/kg (248mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
rabbit | LD50 | intravenous | 36mg/kg (36mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: OTHER CHANGES | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
rabbit | LD50 | oral | 172mg/kg (172mg/kg) | GASTROINTESTINAL: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
rabbit | LD50 | subcutaneous | > 1gm/kg (1000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. | |
rat | LD50 | intraperitoneal | 506mg/kg (506mg/kg) | GASTROINTESTINAL: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
rat | LD50 | intravenous | 82mg/kg (82mg/kg) | GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
rat | LD50 | oral | 4470mg/kg (4470mg/kg) | GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
rat | LD50 | subcutaneous | 2910mg/kg (2910mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 359, 1984. |
women | TDLo | oral | 1008mg/kg/6W- (1008mg/kg) | LIVER: LIVER FUNCTION TESTS IMPAIRED LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" | Annals of Pharmacotherpy. Vol. 33, Pg. 942, 1999. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 4.19 | (none) | EXP | |
Water Solubility | 8.800 | mg/L | 25 | EST |
Vapor Pressure | 1.76E-09 | mm Hg | 25 | EST |
Henry's Law Constant | 3.47E-13 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.84E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.