Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: T-2 toxin
RN: 21259-20-1
UNII: I3FL5NM3MO
InChIKey: BXFOFFBJRFZBQZ-QYWOHJEZSA-N

Note

  • A potent mycotoxin produced in feedstuffs by several species of the genus FUSARIUM. It elicits a severe inflammatory reaction in animals and has teratogenic effects.

Molecular Formula

  • C24-H34-O9

Molecular Weight

  • 466.5236
 

Classification Codes

Classification Codes

  • Mutation Data
  • Natural Product
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • T-2 toxin

MeSH Heading

  • T-2 toxin

Synonyms

  • 12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 4,15-diacetate 8-(3-methylbutanoate)
  • 12,13-Epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol 4,15-diacetate 8-isovalerate
  • 12,13-Epoxytrichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 4,15-diacetate 8-isovalerate
  • 12,13-Trichothecene
  • 3-Hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta(sup 9)-trichothecene
  • 3-Hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecene
  • 3alpha-Hydroxy-4beta-15-diacetoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxy-delta9-tricothecene
  • 4,15-Diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecen-3-ol
  • 4,15-Diacetoxy-8-(3-methylbutyryloxy)scirp-9-en-3-ol
  • 4-beta,15-Diacetoxy-8-alpha-(3-methylbutyryloxy)-3-alpha-hydroxy-12,13-epoxytrichothec-9-ene
  • 8-(3-Methylbutyryloxy)-diacetoxyscirpenol
  • 8alpha-(3-Methylbutyryloxy)-4beta,15-diacetoxyscirp-9-en-3alpha-ol
  • CCRIS 3456
  • EINECS 244-297-7
  • Fusariotoxin T 2
  • Fusariotoxine T2
  • HSDB 3544
  • Insariotoxin
  • Isaritoxin
  • Mycotoxin T-2
  • NSC 138780
  • Scirpenol, 8-(3-methylbutyryloxy)-diacetoxy-
  • T(sub 2)-Trichothecene
  • T-2
  • T-2 mycotoxin
  • T-2 toxin
  • T2 toxin
  • T2-Trichothecene
  • Toxin T2
  • Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-
  • Trichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate
  • UNII-I3FL5NM3MO

Systematic Names

  • (3alpha,4beta,8alpha)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 4,15-diacetate 8-(3-methylbutyrate)
  • T-2 toxin
  • Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)- (9CI)
  • Trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate
  • Trichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate (8CI)

Superlist Names

  • T-2 toxin
  • T2-Trichothecene

Registry Numbers

CAS Registry Number

  • 21259-20-1

FDA UNII

  • I3FL5NM3MO

Other Registry Numbers

  • 11051-21-1
  • 22916-10-5
  • 22916-18-3
  • 25152-34-5
  • 26400-47-5
  • 27640-92-2
  • 36653-66-4
  • 60119-99-5
  • 9061-58-9

System Generated Number

  • 0021259201

Structure Descriptors

InChI

1S/C24H34O9/c1-12(2)7-18(27)32-16-9-23(10-29-14(4)25)17(8-13(16)3)33-21-19(28)20(31-15(5)26)22(23,6)24(21)11-30-24/h8,12,16-17,19-21,28H,7,9-11H2,1-6H3/t16-,17+,19+,20+,21+,22+,23+,24-/m0/s1

InChIKey

BXFOFFBJRFZBQZ-QYWOHJEZSA-N

Smiles

CC1=C[C@@H]2[C@](C[C@@H]1OC(=O)CC(C)C)([C@]3([C@@H]([C@H]([C@H]([C@@]34CO4)O2)O)OC(=O)C)C)COC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 subcutaneous 500ug/kg (0.5mg/kg)   Developments in Food Science. Vol. 4, Pg. 135, 1983.
cattle LD50 oral 600ug/kg (0.6mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE Canadian Veterinary Journal. Vol. 16, Pg. 125, 1975.
cattle LDLo intravenous 1200ug/kg (1.2mg/kg)   Toxicon. Vol. 24, Pg. 13, 1986.
chicken LD50 oral 1840ug/kg (1.84mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Agricultural and Food Chemistry. Vol. 26, Pg. 246, 1978.
guinea pig LC50 inhalation 209mg/m3/10M (209mg/m3) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Fundamental and Applied Toxicology. Vol. 14, Pg. 54, 1990.
guinea pig LD50 intraperitoneal 1200ug/kg (1.2mg/kg)   Fundamental and Applied Toxicology. Vol. 14, Pg. 54, 1990.
guinea pig LD50 intravenous 1300ug/kg (1.3mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 232, Pg. 786, 1985.
guinea pig LD50 oral 1mg/kg (1mg/kg)   Developments in Food Science. Vol. 4, Pg. 135, 1983.
guinea pig LD50 subcutaneous 1mg/kg (1mg/kg)   Human Toxicology. Vol. 4, Pg. 114, 1985.
monkey LD20 intramuscular 650ug/kg (0.65mg/kg)   Toxicology and Applied Pharmacology. Vol. 82, Pg. 532, 1986.
mouse LCLo inhalation 140ppb/30M (0.14ppm) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Fundamental and Applied Toxicology. Vol. 4, Pg. S124, 1984.
mouse LD50 intraperitoneal 3mg/kg (3mg/kg)   National Technical Information Service. Vol. AD-A153-832,
mouse LD50 intravenous 4200ug/kg (4.2mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Fundamental and Applied Toxicology. Vol. 4, Pg. S124, 1984.
mouse LD50 oral 3800ug/kg (3.8mg/kg)   Biotechnology and Bioengineering. Vol. 10, Pg. 445, 1968.
mouse LD50 subcutaneous 2100ug/kg (2.1mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Fundamental and Applied Toxicology. Vol. 4, Pg. S124, 1984.
pig LCLo inhalation 9mg/kg/90M (9mg/kg) LIVER: OTHER CHANGES

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Toxicologic Pathology. Vol. 15, Pg. 308, 1987.
pig LD50 intravenous 1mg/kg (1mg/kg)   Veterinary and Human Toxicology. Vol. 25, Pg. 335, 1983.
pig LD50 oral 4mg/kg (4mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

GASTROINTESTINAL: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Journal of the American Veterinary Medical Association. Vol. 163, Pg. 1278, 1973.
pig LDLo intraarterial 1200ug/kg (1.2mg/kg)   Toxicon. Vol. 24, Pg. 13, 1986.
pigeon LD50 oral 1700ug/kg (1.7mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Toxicology. Vol. 43, Pg. 31, 1987.
rabbit LD50 intramuscular 1100ug/kg (1.1mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 73, Pg. 402, 1984.
rat LC50 inhalation 20mg/m3/10M (20mg/m3)   Fundamental and Applied Toxicology. Vol. 14, Pg. 54, 1990.
rat LD50 intracrebral 60ug/kg (0.06mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives of Toxicology. Vol. 58, Pg. 40, 1985.
rat LD50 intramuscular 470ug/kg (0.47mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL) Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 41, Pg. 924, 1982.
rat LD50 intraperitoneal 900ug/kg (0.9mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: COMA
Toxicon. Vol. 24, Pg. 933, 1986.
rat LD50 intratracheal 4mg/kg (4mg/kg) BLOOD: HEMORRHAGE

ENDOCRINE: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Toxicology. Vol. 43, Pg. 31, 1987.
rat LD50 intravenous 740ug/kg (0.74mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 232, Pg. 786, 1985.
rat LD50 oral 2700ug/kg (2.7mg/kg)   Developments in Food Science. Vol. 4, Pg. 135, 1983.
rat LD50 parenteral 1340ug/kg (1.34mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Toxicology Letters. Vol. 48, Pg. 49, 1989.
rat LD50 skin 2560ug/kg (2.56mg/kg)   National Technical Information Service. Vol. AD-A158-874,
rat LD50 skin 2560ug/kg (2.56mg/kg) BLOOD: OTHER CHANGES

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. AD-A158-874,
rat LD50 subcutaneous 560ug/kg (0.56mg/kg)   Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 41, Pg. 924, 1982.
rat LD50 subcutaneous 560ug/kg (0.56mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL) Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 41, Pg. 924, 1982.
rat LD50 unreported 560ug/kg (0.56mg/kg)   National Technical Information Service. Vol. AD-A158-874,
rat LD50 unreported 560ug/kg (0.56mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: OTHER CHANGES
National Technical Information Service. Vol. AD-A158-874,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 151.5 deg C   EXP
log P (octanol-water) 2.270 (none)   EST
Atmospheric OH Rate Constant 1.55E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.