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Substance Name: Nifenazone [INN:BAN]
RN: 2139-47-1
UNII: 8780F0K71U
InChIKey: BRZANEXCSZCZCI-UHFFFAOYSA-N

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Sensory System Agents

Molecular Formula

  • C17-H16-N4-O2

Molecular Weight

  • 308.3394
 
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Names and Synonyms

Name of Substance

  • Nifenazone
  • Nifenazone [INN:BAN]

Synonyms

  • 2,3-dimethyl-4-nicotinamido-1-phenyl-3-pyrazolin-5-on
  • 4-(Nicotinamido)antipyrine
  • 4-(Nicotinoylamino)antipyrine
  • 4-Nicotinoylamido-1-phenyl-2,3-dimethyl-5-pyrazolone
  • 5-25-14-00153 (Beilstein Handbook Reference)
  • Anicotinoylantipyrine
  • BRN 0307504
  • EINECS 218-387-1
  • N-(2,3-Dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)nicotinamid
  • N-Antipyrinylnicotinamide
  • Niapyrin
  • Nicazane
  • Nicodon
  • Nicodone
  • Nicofesone
  • Nicophesone
  • Nicophezon
  • Nicopyron
  • Nicoreumal
  • Nicoron
  • Nicotazone
  • Nicotinamide, N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)-
  • Nicotinic acid 4-antipyrilamide
  • Nicotinic acid, amidophenyldimethylpyrazolone
  • Nicotinoylaminoantipyrine
  • Nicotinsaeureamidophenyldimethylpyrazolons
  • Nicotinsaeureamidophenyldimethylpyrazolons [German]
  • Nicozone
  • Nifenazon
  • Nifenazona
  • Nifenazona [INN-Spanish]
  • Nifenazone
  • Nifenazonum
  • Nifenazonum [INN-Latin]
  • Nikodon
  • Nikofezon
  • Phenicazone
  • Thylin
  • UNII-8780F0K71U

Systematic Names

  • N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-pyridinecarboxamide (9CI)
  • N-Antipyrinylnicotinamide
  • Nicotinamide, N-antipyrinyl-
  • Nifenazone

Registry Numbers

CAS Registry Number

  • 2139-47-1

FDA UNII

  • 8780F0K71U

System Generated Number

  • 0002139471

Structure Descriptors

InChI

1S/C17H16N4O2/c1-12-15(19-16(22)13-7-6-10-18-11-13)17(23)21(20(12)2)14-8-4-3-5-9-14/h3-11H,1-2H3,(H,19,22)

InChIKey

BRZANEXCSZCZCI-UHFFFAOYSA-N

Smiles

Cc1c(c(=O)n(n1C)c2ccccc2)NC(=O)c3cccnc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1280mg/kg (1280mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 132, 1959.
mouse LD50 oral 7890mg/kg (7890mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 235, 1978.
mouse LD50 subcutaneous 3750mg/kg (3750mg/kg)   Indian Journal of Pharmacy. Vol. 26, Pg. 99, 1964.
mouse LD50 unreported 4200mg/kg (4200mg/kg)   Journal of Drug Research. Vol. 4, Pg. 89, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 253 deg C   EXP
log P (octanol-water) 0.580 (none)   EST
Atmospheric OH Rate Constant 3.35E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.