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Substance Name: Razoxane [INN:BAN]
RN: 21416-67-1
UNII: 5AR83PR647
InChIKey: BMKDZUISNHGIBY-UHFFFAOYSA-N

Notes

  • An antimitotic agent with immunosuppressive properties.
  • An antimitotic agent with immunosuppressive properties. Dexrazoxane, the ( )-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex.

Molecular Formula

  • C11-H16-N4-O4

Molecular Weight

  • 268.2714
 

Classification Codes

  • Antimitotic Agents
  • Antineoplastic Agents
  • Cardiovascular Agents
  • Chelating Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mitosis Modulators
  • Mutation Data
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Razoxane
  • Razoxane [INN:BAN]

MeSH Heading

  • Razoxane

Synonyms

  • (+-)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
  • (+-)-4.4'-Propylenedi-2,6-piperazindion
  • 1,2-Bis(3,5-dioxo-1-piperazinyl)propane
  • 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-
  • 4,4'-Propylenebis(2,6-piperazinedione)
  • 5-24-05-00313 (Beilstein Handbook Reference)
  • AI3-52845
  • BRN 0821182
  • CCRIS 344
  • EINECS 244-379-2
  • ICI 59118
  • ICRF 159
  • ICRF-159
  • NCI-C01627
  • NSC 129943
  • NSC 169780
  • Propylenediazmintetraessigsaeure-diimid
  • Razoxana
  • Razoxana [INN-Spanish]
  • Razoxane
  • Razoxanum
  • Razoxanum [INN-Latin]
  • Razoxin
  • Tepirone
  • Troxozone
  • UNII-5AR83PR647

Systematic Names

  • 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-
  • 2,6-Piperazinedione, 4,4'-propylenedi-
  • 4,4'-Propylenebis(piperazine-2,6-dione)
  • ICRF 159

Superlist Name

  • ICRF-159

Registry Numbers

CAS Registry Number

  • 21416-67-1

FDA UNII

  • 5AR83PR647

Other Registry Numbers

  • 21416-87-5
  • 35259-82-6
  • 78673-26-4
  • 83713-23-9

System Generated Number

  • 0021416671

Structure Descriptors

InChI

1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)

InChIKey

BMKDZUISNHGIBY-UHFFFAOYSA-N

Smiles

CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 81mg/kg/3D-I (81mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: THROMBOCYTOPENIA

BLOOD: LEUKOPENIA
Cancer Chemotherapy Reports, Part 1. Vol. 57, Pg. 185, 1973.
human TDLo oral 500mg/kg (500mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: LEUKOPENIA

BLOOD: THROMBOCYTOPENIA
Cancer Treatment Reports. Vol. 62, Pg. 465, 1978.
man TDLo unreported 6467mg/kg/6Y- (6467mg/kg) BLOOD: THROMBOCYTOPENIA

BLOOD: NORMOCYTIC ANEMIA
British Journal of Dermatology. Vol. 113, Pg. 131, 1985.
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   Chemical and Pharmaceutical Bulletin. Vol. 29, Pg. 1594, 1981.
mouse LD50 intraperitoneal 861mg/kg (861mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
women TDLo oral 3650mg/kg/2Y- (3650mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA

BLOOD: APLASTIC ANEMIA
Lancet. Vol. 2, Pg. 1085, 1987.
women TDLo unreported 600mg/kg/34W- (600mg/kg) BLOOD: LEUKOPENIA British Journal of Dermatology. Vol. 113, Pg. 131, 1985.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 238 deg C   EXP
log P (octanol-water) -3.560 (none)   EST
Atmospheric OH Rate Constant 2.02E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.