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Substance Name: Lofexidine hydrochloride [USAN]
RN: 21498-08-8
UNII: V47G1SDI1B
InChIKey: DWWHMKBNNNZGHF-UHFFFAOYSA-N

Classification Codes

  • Antihypertensive
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Molecular Formula

  • C11-H12-Cl2-N2-O.Cl-H

Molecular Weight

  • 295.596
 
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Names and Synonyms

Name of Substance

  • Lofexidine hydrochloride [USAN]

Synonyms

  • 1H-Imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-, monohydrochloride
  • 2-(1-(2,6-Dichlorophenoxy)ethyl)-2-imidazoline hydrochloride
  • 2-(1-(2,6-Dichlorophenoxy)ethyl)-2-imidazoline monohydrochloride
  • 2-(1-(2,6-Dichlorphenoxy)aethyl)-2-imidazolin-hydrochlorid
  • 2-(1-(2,6-Dichlorphenoxy)aethyl)-2-imidazolin-hydrochlorid [German]
  • BA 168
  • Lofetensin
  • Lofetensin hydrochloride
  • Lofexidine
  • Lofexidine HCl
  • Lofexidine hydrochloride
  • Loxacor
  • Loxacor hydrochloride
  • MDL 14,042
  • RMI-14042A
  • UNII-V47G1SDI1B

Systematic Names

  • 1H-Imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-, monohydrochloride
  • 2-Imidazoline, 2-(1-(2,6-dichlorophenoxy)ethyl)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 21498-08-8

FDA UNII

  • V47G1SDI1B

Related Registry Number

  • 31036-80-3 (Parent)

System Generated Number

  • 0021498088

Molecular Formulas

Molecular Formula

  • C11-H12-Cl2-N2-O.Cl-H

Molecular Formula Fragments

  • C11-H12-Cl2-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13;/h2-4,7H,5-6H2,1H3,(H,14,15);1H

InChIKey

DWWHMKBNNNZGHF-UHFFFAOYSA-N

Smiles

Cl.CC(Oc1c(Cl)cccc1Cl)C2=NCCN2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 8mg/kg (8mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982.
dog LD50 oral 70mg/kg (70mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982.
human TDLo oral 270ug/kg/6W-I (0.27mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: HEADACHE
Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 976, 1982.
mouse LD50 intravenous 8mg/kg (8mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982.
mouse LD50 oral 54mg/kg (54mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 966, 1982.
rat LD50 intravenous 8mg/kg (8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982.
rat LD50 oral 70mg/kg (70mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982.