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Substance Name: Mianserin hydrochloride [USAN:JAN]
RN: 21535-47-7
UNII: 2X03TN217S
InChIKey: YNPFMWCWRVTGKJ-UHFFFAOYSA-N
Note
- A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
Molecular Formula
- C18-H20-N2.Cl-H
Molecular Weight
- 300.8309
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Antihistaminic
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
- Serotonin Inhibitor
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Names and Synonyms
Name of Substance
- Mianserin hydrochloride
- Mianserin hydrochloride [USAN:JAN]
Synonyms
- 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)-pyrazino(1,2-a)azepine monohydrochloride
- 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine hydrochloride
- Athymil
- Bolvidon
- Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, monohydrochloride
- EINECS 244-426-7
- GB 94
- Lerivon
- Mianserin HCl
- Mianserin hydrochloride
- Mianserine hydrochloride
- Norval
- NSC 759590
- ORG GB 94
- Tolvin
- Tolvon
- UNII-2X03TN217S
Systematic Names
- Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, monohydrochloride
- Mianserin hydrochloride
Registry Numbers
CAS Registry Number
- 21535-47-7
FDA UNII
- 2X03TN217S
Related Registry Number
- 24219-97-4 (Parent)
System Generated Number
- 0021535477
Molecular Formulas
Molecular Formula
- C18-H20-N2.Cl-H
Molecular Formula Fragments
- C18-H20-N2
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1HInChIKey
YNPFMWCWRVTGKJ-UHFFFAOYSA-NSmiles
Cl.CN1CCN2C(C1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
monkey | LDLo | oral | 200mg/kg (200mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE | Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 56, 1981. |
mouse | LD50 | intraperitoneal | 117mg/kg (117mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983. | |
mouse | LD50 | intravenous | 31mg/kg (31mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 56, 1981. |
mouse | LD50 | oral | 224mg/kg (224mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 31, Pg. 112, 1979. |
mouse | LD50 | subcutaneous | 118mg/kg (118mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 31, Pg. 112, 1979. |
rat | LD50 | intraperitoneal | 262mg/kg (262mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 31, Pg. 112, 1979. |
rat | LD50 | intravenous | 31850ug/kg (31.85mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983. | |
rat | LD50 | oral | 780mg/kg (780mg/kg) | BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 56, 1981. |
rat | LD50 | subcutaneous | > 3gm/kg (3000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 31, Pg. 112, 1979. |
women | TDLo | oral | 18mg/kg (18mg/kg) | CARDIAC: PULSE RATE BEHAVIORAL: COMA CARDIAC: OTHER CHANGES | Human Toxicology. Vol. 6, Pg. 401, 1987. |
women | TDLo | oral | 28mg/kg/5W (28mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES CARDIAC: CHANGE IN RATE BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | British Medical Journal. Vol. 284, Pg. 1912, 1982. |