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Substance Name: Mianserin hydrochloride [USAN:JAN]
RN: 21535-47-7
UNII: 2X03TN217S
InChIKey: YNPFMWCWRVTGKJ-UHFFFAOYSA-N

Note

  • A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.

Molecular Formula

  • C18-H20-N2.Cl-H

Molecular Weight

  • 300.8309
 

Classification Codes

  • Antihistaminic
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Serotonin Inhibitor
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Names and Synonyms

Name of Substance

  • Mianserin hydrochloride
  • Mianserin hydrochloride [USAN:JAN]

Synonyms

  • 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)-pyrazino(1,2-a)azepine monohydrochloride
  • 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine hydrochloride
  • Athymil
  • Bolvidon
  • Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, monohydrochloride
  • EINECS 244-426-7
  • GB 94
  • Lerivon
  • Mianserin HCl
  • Mianserin hydrochloride
  • Mianserine hydrochloride
  • Norval
  • ORG GB 94
  • Tolvin
  • Tolvon
  • UNII-2X03TN217S

Systematic Names

  • Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, monohydrochloride
  • Mianserin hydrochloride

Registry Numbers

CAS Registry Number

  • 21535-47-7

FDA UNII

  • 2X03TN217S

Related Registry Number

  • 24219-97-4 (Parent)

System Generated Number

  • 0021535477

Molecular Formulas

Molecular Formula

  • C18-H20-N2.Cl-H

Molecular Formula Fragments

  • C18-H20-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H

InChIKey

YNPFMWCWRVTGKJ-UHFFFAOYSA-N

Smiles

CN1CCN2c3ccccc3Cc4ccccc4C2C1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LDLo oral 200mg/kg (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 56, 1981.
mouse LD50 intraperitoneal 117mg/kg (117mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse LD50 intravenous 31mg/kg (31mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 56, 1981.
mouse LD50 oral 224mg/kg (224mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 31, Pg. 112, 1979.
mouse LD50 subcutaneous 118mg/kg (118mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 31, Pg. 112, 1979.
rat LD50 intraperitoneal 262mg/kg (262mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 31, Pg. 112, 1979.
rat LD50 intravenous 31850ug/kg (31.85mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
rat LD50 oral 780mg/kg (780mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 56, 1981.
rat LD50 subcutaneous > 3gm/kg (3000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 31, Pg. 112, 1979.
women TDLo oral 18mg/kg (18mg/kg) CARDIAC: PULSE RATE

BEHAVIORAL: COMA

CARDIAC: OTHER CHANGES
Human Toxicology. Vol. 6, Pg. 401, 1987.
women TDLo oral 28mg/kg/5W (28mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

CARDIAC: CHANGE IN RATE

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
British Medical Journal. Vol. 284, Pg. 1912, 1982.