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Substance Name: Leptophos [ISO]
RN: 21609-90-5
UNII: C45E8FUG3Z
InChIKey: CVRALZAYCYJELZ-UHFFFAOYSA-N

Note

  • An organothiophosphate insecticide.

Molecular Formula

  • C13-H10-Br-Cl2-O2-P-S

Molecular Weight

  • 412.07
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Drug / Therapeutic Agent
  • Insecticide
  • Insecticides
  • Mutation Data
  • Out-Dated Pesticide
  • Pesticides
  • Reproductive Effect

Superlist Classification Code

  • Threshold Planning Quantity (TPQ) = 500/10000 lb
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Names and Synonyms

Name of Substance

  • Leptophos [ISO]

MeSH Heading

  • Leptophos

Synonyms

  • (+-)-Leptophos
  • Abar
  • Abar (velsicol)
  • AI3-27378
  • BRN 2152663
  • Caswell No. 525B
  • EINECS 244-472-8
  • EPA Pesticide Chemical Code 525300
  • Fosvel
  • HSDB 2621
  • K62-105
  • Leptophos
  • MBCP
  • NK 711
  • O-(2,5-Dichloro-4-bromophenyl) O-methyl phenylthiophosphonate
  • O-(4-Bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate
  • O-Methyl O-2,5-dichloro-4-bromophenyl phenylthiophosphonate
  • O-Methyl-O-(4-bromo-2,5-dichlorophenyl)phenyl thiophosphonate
  • Oleophosvel
  • OMS 1438
  • Phenylphosphonothioic acid O-(4-bromo-2,5-dichlorophenyl) O-methyl ester
  • Phosphonothioic acid, phenyl-, O-(4-bromo-2,5-dichlorophenyl) O-methyl ester (8CI)(9CI)
  • Phosvel
  • UNII-C45E8FUG3Z
  • VCS 5-D
  • VCS-506
  • Velsicol 506
  • Velsicol VCS 506

Systematic Names

  • Leptophos
  • Phosphonothioic acid, phenyl-, O-(4-bromo-2,5-dichlorophenyl) O-methyl ester

Superlist Name

  • Leptophos

Registry Numbers

CAS Registry Number

  • 21609-90-5

FDA UNII

  • C45E8FUG3Z

Other Registry Number

  • 73270-49-2

System Generated Number

  • 0021609905

Structure Descriptors

InChI

1S/C13H10BrCl2O2PS/c1-17-19(20,9-5-3-2-4-6-9)18-13-8-11(15)10(14)7-12(13)16/h2-8H,1H3

InChIKey

CVRALZAYCYJELZ-UHFFFAOYSA-N

Smiles

COP(=S)(Oc1cc(Cl)c(Br)cc1Cl)c2ccccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo skin 2250mg/kg (2250mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
National Technical Information Service. Vol. OTS0543229,
chicken LD intravenous > 30mg/kg (30mg/kg)   Environmental Health and Preventive Medicine.
chicken LD intravenous > 30mg/kg (30mg/kg)   Environmental Health and Preventive Medicine.
chicken LD intravenous > 30mg/kg (30mg/kg) BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" Environmental Health and Preventive Medicine.
chicken LD50 oral 4700mg/kg (4700mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: ATAXIA
Experientia. Vol. 30, Pg. 63, 1974.
mammal (species unspecified) LD50 skin 50mg/kg (50mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 21(7), Pg. 34, 1977.
mouse LD50 oral 65mg/kg (65mg/kg)   Journal of Agricultural and Food Chemistry. Vol. 27, Pg. 1197, 1979.
mouse LD50 oral 71900ug/kg (71.9mg/kg)   Journal of Agricultural and Food Chemistry. Vol. 28, Pg. 594, 1980.
mouse LD50 subcutaneous 120mg/kg (120mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 74, 1969.
rabbit LD50 oral 124mg/kg (124mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Journal Europeen de Toxicologie. Vol. 6, Pg. 70, 1973.
rabbit LD50 skin 800mg/kg (800mg/kg)   Journal Europeen de Toxicologie. Vol. 6, Pg. 70, 1973.
rat LD50 intraperitoneal 135mg/kg (135mg/kg) BLOOD: HEMORRHAGE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 373, 1981.
rat LD50 oral 19mg/kg (19mg/kg)   Fundamental and Applied Toxicology. Vol. 7, Pg. 299, 1986.
rat LD50 skin 44mg/kg (44mg/kg)   Fundamental and Applied Toxicology. Vol. 7, Pg. 299, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 70.4 deg C   EXP
log P (octanol-water) 6.31 (none)   EXP
Water Solubility 0.03 mg/L 24 EXP
Vapor Pressure 2.30E-08 mm Hg 20 EXP
Henry's Law Constant 2.65E-06 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.80E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.