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Substance Name: Diftalone [USAN:INN]
RN: 21626-89-1
UNII: 142FG4G74X
InChIKey: CXSJGNHRBWJXEA-UHFFFAOYSA-N

Note

  • Has sedative & antipyretic properties.

Classification Code

  • Anti-Inflammatory

Molecular Formula

  • C16-H12-N2-O2

Molecular Weight

  • 264.283
 
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Names and Synonyms

Name of Substance

  • Diftalone
  • Diftalone [USAN:INN]

Synonyms

  • 5-24-08-00461 (Beilstein Handbook Reference)
  • Aladione
  • BRN 0753163
  • CCRIS 5458
  • DFL
  • Diftalona
  • Diftalona [INN-Spanish]
  • Diftalone
  • Diftalonum
  • Diftalonum [INN-Latin]
  • EINECS 244-484-3
  • L 5418
  • L-5418
  • Phthalazino(2,3-b)phthalazine-5,12(7H,14H)-dione
  • UNII-142FG4G74X

Systematic Names

  • Diftalone
  • Phthalazino(2,3-b)phthalazine-5(14H),12(7H)-dione
  • Phthalazino(2,3-b)phthalazine-5,12(7H,14H)-dione

Registry Numbers

CAS Registry Number

  • 21626-89-1

FDA UNII

  • 142FG4G74X

System Generated Number

  • 0021626891

Structure Descriptors

InChI

1S/C16H12N2O2/c19-15-13-7-3-1-5-11(13)9-17-16(20)14-8-4-2-6-12(14)10-18(15)17/h1-8H,9-10H2

InChIKey

CXSJGNHRBWJXEA-UHFFFAOYSA-N

Smiles

N12N(C(c3ccccc3C2)=O)Cc2ccccc2C1=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular > 3gm/kg (3000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 352, 1975.
mouse LD50 intraperitoneal 1600mg/kg (1600mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 70, Pg. 479, 1974.
mouse LD50 oral 6350mg/kg (6350mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 2003, 1974.
mouse LD50 subcutaneous > 7500mg/kg (7500mg/kg)   Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 352, 1975.
rat LD50 intramuscular > 3gm/kg (3000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 352, 1975.
rat LD50 intraperitoneal 1970mg/kg (1970mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 70, Pg. 479, 1974.
rat LD50 oral > 10gm/kg (10000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 70, Pg. 479, 1974.
rat LD50 subcutaneous > 7500mg/kg (7500mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 352, 1975.