Skip Navigation
ChemIDplus A TOXNET DATABASE Lite•Browse•Advanced

Substance Name: Fludarabine [INN]
RN: 21679-14-1
UNII: P2K93U8740
InChIKey: HBUBKKRHXORPQB-FJFJXFQQSA-N

Classification Codes

  • Antineoplastic Agents
  • Mutation Data

Molecular Formula

  • C10-H12-F-N5-O4

Molecular Weight

  • 285.2338
 

Names and Synonyms

Name of Substance

  • Fludarabine
  • Fludarabine [INN]

Synonyms

  • 2-Fluoro Ara-A
  • 2-Fluoro-9-beta-D-arabinofuranosyladenine
  • 9-beta-D-Arabinofuranosyl-2-fluoroadenine
  • CCRIS 3382
  • EINECS 244-525-5
  • F-Ara-A
  • Fludarabina
  • Fludarabina [Spanish]
  • Fludarabine
  • Fludarabinum
  • Fludarabinum [Latin]
  • HSDB 6964
  • NSC 118218
  • NSC 118218H
  • UNII-P2K93U8740

Systematic Names

  • 9-beta-D-Arabinofuranosyl-2-fluoroadenine
  • 9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- (9CI)
  • Adenine, 9-beta-D-arabinofuranosyl-2-fluoro-
  • Fludarabine

Registry Numbers

CAS Registry Number

  • 21679-14-1

FDA UNII

  • P2K93U8740

System Generated Number

  • 0021679141

Structure Descriptors

InChI

1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1

InChIKey

HBUBKKRHXORPQB-FJFJXFQQSA-N

Smiles

c12n([C@H]3O[C@@H]([C@H]([C@@H]3O)O)CO)cnc1c(nc(n2)F)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 375mg/kg (375mg/kg)   Cancer Research. Vol. 42, Pg. 2587, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 260 deg C   EXP
log P (octanol-water) -1.180 (none)   EST
Water Solubility 3530 mg/L 25 EST
Vapor Pressure 3.70E-15 mm Hg 25 EST
Henry's Law Constant 1.30E-22 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.38E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.