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Substance Name: Etifoxine [INN:BAN:DCF]
RN: 21715-46-8
UNII: X24X82MX4X
InChIKey: IBYCYJFUEJQSMK-UHFFFAOYSA-N

Classification Codes

  • Anti-Anxiety Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Psychotropic Drugs
  • Tranquilizing Agents

Molecular Formula

  • C17-H17-Cl-N2-O

Molecular Weight

  • 300.787
 
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Names and Synonyms

Name of Substance

  • Etifoxine
  • Etifoxine [INN:BAN:DCF]

Synonyms

  • 2-Aethylamino-6-chlor-4-methyl-4-phenyl-4H-3,1-benzoxazin
  • 2-Aethylamino-6-chlor-4-methyl-4-phenyl-4H-3,1-benzoxazin [German]
  • 36-801
  • 6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine
  • BRN 0548223
  • Etifoxin
  • Etifoxina
  • Etifoxina [INN-Spanish]
  • Etifoxina [Spanish]
  • Etifoxine
  • Etifoxinum
  • Etifoxinum [INN-Latin]
  • Etifoxinum [Latin]
  • HOE 36801
  • UNII-X24X82MX4X

Systematic Names

  • 4H-3,1-Benzoxazin-2-amine, 6-chloro-N-ethyl-4-methyl-4-phenyl- (9CI)
  • 4H-3,1-Benzoxazine, 6-chloro-2-ethylamino-4-methyl-4-phenyl-
  • 6-Chloro-2-(ethylamino)-4-methyl-4-phenyl-4H-3,1-benzoxazine

Registry Numbers

CAS Registry Number

  • 21715-46-8

FDA UNII

  • X24X82MX4X

System Generated Number

  • 0021715468

Structure Descriptors

InChI

1S/C17H17ClN2O/c1-3-19-16-20-15-10-9-13(18)11-14(15)17(2,21-16)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3,(H,19,20)

InChIKey

IBYCYJFUEJQSMK-UHFFFAOYSA-N

Smiles

c12[C@@](c3ccccc3)(OC(NCC)=Nc1ccc(c2)Cl)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 133mg/kg (133mg/kg)   Therapie. Vol. 27, Pg. 325, 1972.
mouse LD50 intraperitoneal 450mg/kg (450mg/kg)   Therapie. Vol. 27, Pg. 325, 1972.
mouse LD50 intravenous 120mg/kg (120mg/kg)   Therapie. Vol. 27, Pg. 325, 1972.
mouse LD50 oral 1388mg/kg (1388mg/kg)   Therapie. Vol. 27, Pg. 325, 1972.
rat LD50 intraperitoneal 292mg/kg (292mg/kg)   Therapie. Vol. 27, Pg. 325, 1972.
rat LD50 intravenous 55mg/kg (55mg/kg)   Therapie. Vol. 27, Pg. 325, 1972.
rat LD50 oral 1500mg/kg (1500mg/kg)   Therapie. Vol. 27, Pg. 325, 1972.