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Substance Name: Spectinomycin hydrochloride
RN: 21736-83-4
UNII: 296JEI210Z
InChIKey: FOGDPGQSHLLYIK-XYQGXRRISA-N

Note

  • An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.

Molecular Formula

  • C14-H24-N2-O7.2Cl-H

Molecular Weight

  • 405.2724
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Results Name

  • Spectinomycin hydrochloride

Name of Substance

  • Spectinomycin hydrochloride anhydrous

Synonyms

  • EINECS 244-554-3
  • NSC 248616
  • Spectam Scour Halt
  • Spectinomycin dihydrochloride
  • Spectinomycin HCl
  • Spectogard
  • Stanilo
  • Trobicin
  • UNII-296JEI210Z

Systematic Names

  • 4H-Pyrano(2,3-b)(1,4)benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-
  • 4H-Pyrano(2,3-b)(1,4)benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, (2R-(2-alpha,4a-beta,5a-beta,6-beta,7-beta,8-beta,9-alpha,9a-alpha,10a-beta))-
  • Spectinomycin dihydrochloride

Registry Numbers

CAS Registry Number

  • 21736-83-4

FDA UNII

  • 296JEI210Z

Related Registry Number

  • 1695-77-8 (Parent)

System Generated Number

  • 0021736834

Molecular Formulas

Molecular Formula

  • C14-H24-N2-O7.2Cl-H

Molecular Formula Fragments

  • C14-H24-N2-O7
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C14H24N2O7.2ClH/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;/m1../s1

InChIKey

FOGDPGQSHLLYIK-XYQGXRRISA-N

Smiles

C[C@@H]1CC(=O)[C@]2([C@@H](O1)O[C@@H]3[C@H]([C@@H]([C@@H]([C@@H]([C@H]3O2)[NH2+]C)O)[NH2+]C)O)O.[Cl-].[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 oral 500mg/kg (500mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 7, Pg. 100, 1965.
mouse LD50 intramuscular > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 382, 1982.
mouse LD50 intraperitoneal 2350mg/kg (2350mg/kg)   Drugs in Japan Vol. 6, Pg. 382, 1982.
mouse LD50 intravenous 2850ug/kg (2.85mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 7, Pg. 100, 1965.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 382, 1982.
mouse LD50 subcutaneous 8400mg/kg (8400mg/kg)   Drugs in Japan Vol. 6, Pg. 382, 1982.
rat LD50 intramuscular > 2500mg/kg (2500mg/kg)   Drugs in Japan Vol. 6, Pg. 382, 1982.
rat LD50 intraperitoneal 2020mg/kg (2020mg/kg)   Drugs in Japan Vol. 6, Pg. 382, 1982.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 382, 1982.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 382, 1982.