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Substance Name: Bardoxolone [USAN:INN]
RN: 218600-44-3
UNII: 7HT68L8941
InChIKey: TXGZJQLMVSIZEI-UQMAOPSPSA-N

Note

  • NCI: A synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression. (NCI Thesaurus)

Molecular Formula

  • C31-H41-N-O4

Molecular Weight

  • 491.6679
 

Classification Code

  • Antineoplastic and Anti-Inflammatory
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Names and Synonyms

Name of Substance

  • Bardoxolone
  • Bardoxolone [USAN:INN]

Synonyms

  • (+)-2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid
  • Bardoxolone
  • CDDO
  • RTA 401
  • UNII-7HT68L8941

Systematic Name

  • Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-

Registry Numbers

CAS Registry Number

  • 218600-44-3

FDA UNII

  • 7HT68L8941

System Generated Number

  • 0218600443

Structure Descriptors

InChI

1S/C31H41NO4/c1-26(2)10-12-31(25(35)36)13-11-30(7)23(19(31)16-26)20(33)14-22-28(5)15-18(17-32)24(34)27(3,4)21(28)8-9-29(22,30)6/h14-15,19,21,23H,8-13,16H2,1-7H3,(H,35,36)/t19-,21-,23-,28-,29+,30+,31-/m0/s1

InChIKey

TXGZJQLMVSIZEI-UQMAOPSPSA-N