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Substance Name: Bardoxolone methyl [USAN]
RN: 218600-53-4
UNII: CEG1Q6OGU1
InChIKey: WPTTVJLTNAWYAO-KPOXMGGZSA-N

Note

  • NCI: A synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression. /Bardoxolone/ (NCI Thesaurus)

Molecular Formula

  • C32-H43-N-O4

Molecular Weight

  • 505.6947
 

Classification Code

  • Anti-Inflammatory
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Names and Synonyms

Name of Substance

  • Bardoxolone methyl [USAN]
  • Methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate

Synonyms

  • (+)-methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate
  • 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid methyl ester
  • Bardoxolone methyl
  • CDDO Methyl ester
  • CDDO-Me
  • NSC 713200
  • RTA 402
  • UNII-CEG1Q6OGU1

Systematic Name

  • Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester

Registry Numbers

CAS Registry Number

  • 218600-53-4

FDA UNII

  • CEG1Q6OGU1

System Generated Number

  • 0218600534

Structure Descriptors

InChI

1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1

InChIKey

WPTTVJLTNAWYAO-KPOXMGGZSA-N