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Substance Name: Dexetimide hydrochloride
RN: 21888-96-0
UNII: B987A3XX7D
InChIKey: XSOOSXRNMDUWEM-GNAFDRTKSA-N

Note

  • A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.

Molecular Formula

  • C23-H26-N2-O2.Cl-H

Molecular Weight

  • 398.931
 

Classification Codes

  • Anticholinergic
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Dexetimide hydrochloride

Synonyms

  • (+)-1-Benzyl-4-(2,6-dioxo-3-phenyl-3-piperidyl)piperidine hydrochloride
  • (+)-2-(1-Benzyl-4-piperidyl)-2-phenylglutarimide hydrochloride
  • (+)-3-(1-Benzyl-4-piperidyl)-3-phenylpiperidine-2,6-dione hydrochloride
  • (S)-3-Phenyl-1'-(phenylmethyl)-(3,4'-bipiperidine)-2,6-dione hydrochloride
  • Dexbenzetimide hydrochloride
  • Dexetimide HCl
  • Dexetimide hydrochloride
  • Dextrobenzetimide hydrochloride
  • EINECS 244-633-2
  • R 16470
  • Tremblex
  • UNII-B987A3XX7D

Systematic Names

  • (3,4'-Bipiperidine)-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, hydrochloride, (S)-
  • (S)-3-Phenyl-1'-(phenylmethyl)(3,4'-bipiperidine)-2,6-dione monohydrochloride

Registry Numbers

CAS Registry Number

  • 21888-96-0

FDA UNII

  • B987A3XX7D

System Generated Number

  • 0021888960

Molecular Formulas

Molecular Formula

  • C23-H26-N2-O2.Cl-H

Molecular Formula Fragments

  • C23-H26-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C23H26N2O2.ClH/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18;/h1-10,20H,11-17H2,(H,24,26,27);1H/t23-;/m1./s1

InChIKey

XSOOSXRNMDUWEM-GNAFDRTKSA-N

Smiles

C1([C@@]2(c3ccccc3)C(NC(=O)CC2)=O)CC[NH+](Cc2ccccc2)CC1.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 45mg/kg (45mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1365, 1971.
rat LD50 intravenous 45mg/kg (45mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 219, 1972.