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Substance Name: Dexetimide [USAN:INN:BAN]
RN: 21888-98-2
UNII: 43477QYX3D
InChIKey: LQQIVYSCPWCSSD-HSZRJFAPSA-N

Note

  • A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.

Molecular Formula

  • C23-H26-N2-O2

Molecular Weight

  • 362.4704
 

Classification Codes

  • Anti-Dyskinesia Agents
  • Anticholinergic
  • Antiparkinson Agents
  • Autonomic Agents
  • Central Nervous System Agents
  • Cholinergic Agents
  • Cholinergic Antagonists
  • Muscarinic Antagonists
  • Neurotransmitter Agents
  • Parasympatholytics
  • Peripheral Nervous System Agents
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Names and Synonyms

Name of Substance

  • Dexetimide
  • Dexetimide [USAN:INN:BAN]

MeSH Heading

  • Dexetimide

Synonyms

  • (+)-(R)-3-(1-Benzyl-4-piperidyl)-3-phenyl-2,6-piperidindion
  • (+)-2-(1-Benzyl-4-piperidyl)-2-phenylglutarimide
  • (3,4'-Bipiperidine)-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (S)-
  • Dexbenzelimid
  • Dexetimida
  • Dexetimida [INN-Spanish]
  • Dexetimide
  • Dexetimidum
  • Dexetimidum [INN-Latin]
  • R 16,470 [as hydrochloride]
  • R 16470
  • Serenone
  • Tremblex
  • UNII-43477QYX3D

Systematic Name

  • (3,4'-Bipiperidine)-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (S)-

Registry Numbers

CAS Registry Number

  • 21888-98-2

FDA UNII

  • 43477QYX3D

System Generated Number

  • 0021888982

Structure Descriptors

InChI

1S/C23H26N2O2/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18/h1-10,20H,11-17H2,(H,24,26,27)/t23-/m1/s1

InChIKey

LQQIVYSCPWCSSD-HSZRJFAPSA-N

Smiles

O=C1CC[C@@](C2CCN(Cc3ccccc3)CC2)(C(=O)N1)c4ccccc4

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.55 (none)   EXP
Water Solubility 4.840 mg/L 25 EST
Vapor Pressure 3.10E-14 mm Hg 25 EST
Henry's Law Constant 1.49E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.40E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.