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Substance Name: Clenbuterol hydrochloride [USP:JAN]
RN: 21898-19-1
UNII: GOR5747GWU
InChIKey: OPXKTCUYRHXSBK-UHFFFAOYSA-N

Note

  • A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma.

Molecular Formula

  • C12-H18-Cl2-N2-O.Cl-H

Molecular Weight

  • 313.6541
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Clenbuterol hydrochloride
  • Clenbuterol hydrochloride [USP:JAN]

Synonyms

  • (1)-4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol monohydrochloride
  • 4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol hydrochloride
  • 4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzylalkohol-hydrochlorid
  • 4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzylalkohol-hydrochlorid [German]
  • Clenasma
  • Clenbuterol clorhidrato
  • Clenbuterol clorhidrato [Spanish]
  • Clenbuterol HCl
  • Clenbuterol hydrochloride
  • Contrasmina
  • EINECS 244-643-7
  • EINECS 274-226-5
  • Monores
  • NAB 365
  • Planipart hydrochloride
  • Spiropent
  • UNII-GOR5747GWU
  • Ventipulmin

Systematic Names

  • 4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcoholmonohydrochloride
  • Benzyl alcohol, 4-amino-alpha-((tert-butylamino)methyl)-3,5-dichloro-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 21898-19-1

FDA UNII

  • GOR5747GWU

Other Registry Numbers

  • 53144-57-3
  • 69930-61-6

System Generated Number

  • 0021898191

Molecular Formulas

Molecular Formula

  • C12-H18-Cl2-N2-O.Cl-H

Molecular Formula Fragments

  • C12-H18-Cl2-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H

InChIKey

OPXKTCUYRHXSBK-UHFFFAOYSA-N

Smiles

C(NCC(c1cc(c(c(c1)Cl)N)Cl)O)(C)(C)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 45mg/kg (45mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976.
dog LDLo oral 500mg/kg (500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976.
guinea pig LD50 intravenous 12600ug/kg (12.6mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976.
guinea pig LD50 subcutaneous 67100ug/kg (67.1mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976.
mouse LD50 intraperitoneal 46mg/kg (46mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

CARDIAC: CHANGE IN RATE
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 675, 1975.
mouse LD50 intravenous 27600ug/kg (27.6mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976.
mouse LD50 oral 147mg/kg (147mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 741, 1984.
mouse LD50 subcutaneous 63mg/kg (63mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 741, 1984.
rabbit LD50 intravenous 12600ug/kg (12.6mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1404, 1976.
rabbit LD50 subcutaneous 67100ug/kg (67.1mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1404, 1976.
rat LD50 intraperitoneal 67mg/kg (67mg/kg) CARDIAC: CHANGE IN RATE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 675, 1975.
rat LD50 intravenous 35300ug/kg (35.3mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976.
rat LD50 oral 159mg/kg (159mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 741, 1984.
rat LD50 subcutaneous 148mg/kg (148mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 741, 1984.