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Substance Name: Etafenone hydrochloride [JAN]
RN: 2192-21-4
UNII: NTS160XKGC
InChIKey: BYWIEEUABBZFEE-UHFFFAOYSA-N

Note

  • Used in therapy of anigna pectoris.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H27-N-O2.Cl-H

Molecular Weight

  • 361.91
 
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Names and Synonyms

Name of Substance

  • Etafenone hydrochloride [JAN]

Synonyms

  • (O-beta-Diethylaminoethoxy)-phenyl propiophenone hydrochloride
  • 1-(2-(2-(Diethylamino)ethoxy)phenyl)-3-phenyl-1-propanone
  • 1-(2-(2-(Diethylamino)ethoxy)phenyl)-3-phenyl-1-propanone hydrochloride
  • Asamedel
  • Baxacor
  • beta-Phenyl-o-(diethylaminoethoxy)propiophenone hydrochloride
  • Cardilicor
  • Corodilan
  • Corofenon
  • Coronabason
  • Dialicor
  • EINECS 218-587-9
  • Esanthin-S
  • Etafenarin
  • Etafenone HCl
  • Etafenone hydrochloride
  • Etafon hydrochloride
  • Hetaphenone
  • Hypochit
  • L.G. 11,457 hydrochloride
  • L.g.11,457
  • NSC 166350
  • o-((beta-(diethylamino)ethoxy)phenyl)propiophenone hydrochloride
  • o-(beta-Diethylaminoethoxy)phenylpropiophenonehydrochloride
  • Pagano-cor
  • Relicor
  • Relicor hydrochloride
  • UNII-NTS160XKGC

Systematic Names

  • 1-Propanone, 1-(2-(2-(diethylamino)ethoxy)phenyl)-3-phenyl-, hydrochloride (9CI)
  • 2'-(2-(Diethylamino)ethoxy)-3-phenylpropiophenone hydrochloride
  • Propiophenone, 2'-(2-(diethylamino)ethoxy)-3-phenyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 2192-21-4

FDA UNII

  • NTS160XKGC

Related Registry Number

  • 90-54-0 (Parent)

System Generated Number

  • 0002192214

Molecular Formulas

Molecular Formula

  • C21-H27-N-O2.Cl-H

Molecular Formula Fragments

  • C21-H27-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H27NO2.ClH/c1-3-22(4-2)16-17-24-21-13-9-8-12-19(21)20(23)15-14-18-10-6-5-7-11-18;/h5-13H,3-4,14-17H2,1-2H3;1H

InChIKey

BYWIEEUABBZFEE-UHFFFAOYSA-N

Smiles

c1(C(=O)CCc2ccccc2)c(OCCN(CC)CC)cccc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 50mg/kg (50mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1664, 1969.
mouse LD50 intraperitoneal 90mg/kg (90mg/kg)   Drugs in Japan Vol. -, Pg. 180, 1990.
mouse LD50 intravenous 28mg/kg (28mg/kg)   Pharmaceutical Chemistry Journal Vol. 23, Pg. 966, 1989.
mouse LD50 oral 352mg/kg (352mg/kg)   Drugs in Japan Vol. 6, Pg. 109, 1982.
mouse LD50 subcutaneous 234mg/kg (234mg/kg)   Pharmaceutical Chemistry Journal Vol. 21, Pg. 646, 1987.
rat LD50 intraperitoneal 66mg/kg (66mg/kg)   Drugs in Japan Vol. -, Pg. 180, 1990.
rat LD50 intravenous 20800ug/kg (20.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1664, 1969.
rat LD50 oral 716mg/kg (716mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1664, 1969.
rat LD50 subcutaneous 1900mg/kg (1900mg/kg)   Drugs in Japan Vol. -, Pg. 180, 1990.