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Substance Name: Imatinib mesylate [USAN]
RN: 220127-57-1
UNII: 8A1O1M485B
InChIKey: YLMAHDNUQAMNNX-UHFFFAOYSA-N

Note

  • A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors.

Molecular Formula

  • C29-H31-N7-O.C-H4-O3-S

Molecular Weight

  • 589.7175
 

Classification Codes

  • Anti-Leukemia and Anti-Tumor Agent (Tyrosine Kinase Inhibitor)
  • Antineoplastic
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors

Names and Synonyms

Name of Substance

  • Imatinib mesylate
  • Imatinib mesylate [USAN]

MeSH Heading

  • Imatinib Mesylate

Synonyms

  • CGP 57148B
  • Gleevec
  • Glivec
  • HSDB 7142
  • Imatinib mesilate
  • Imatinib mesylate
  • Imatinib methanesulfonate
  • Imatinib monomethanesulfonate
  • Shantinib
  • STI 571
  • STI571
  • UNII-8A1O1M485B

Systematic Name

  • Benzamide, 4-((4-methyl-1-piperazinyl)methyl)-N-(4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)phenyl)-, monomethanesulfonate

Registry Numbers

CAS Registry Number

  • 220127-57-1

FDA UNII

  • 8A1O1M485B

System Generated Number

  • 0220127571

Molecular Formulas

Molecular Formula

  • C29-H31-N7-O.C-H4-O3-S

Molecular Formula Fragments

  • C-H4-O3-S
  • C29-H31-N7-O
  • COMPONENT

Structure Descriptors

InChI

1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)

InChIKey

YLMAHDNUQAMNNX-UHFFFAOYSA-N

Smiles

C1N(C)CCN(C1)Cc1ccc(cc1)C(Nc1ccc(c(c1)Nc1nccc(n1)c1cccnc1)C)=O.OS(C)(=O)=O