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Substance Name: Gemtuzumab ozogamicin [USAN]
RN: 220578-59-6

Note

  • An anti-CD33 antibody calicheamicin conjugate.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Antineoplastic Agents
  • Antineoplastic Agents, Immunological
  • Immunotoxins
  • Noxae
  • Treatment of Relapsed, Acute Myelogenous Leukemia (Cytotoxic Calicheamicin Derivative Conjugated to a Humanized Monoclonal Antibody)

Names and Synonyms

Name of Substance

  • Gemtuzumab ozogamicin [USAN]
  • Gemtuzumab [INN]

Synonyms

  • CDP 771
  • CDP-771
  • CMA 676
  • CMA-676
  • Gemtuzumab
  • Gemtuzumab ozogamicin
  • Immunoglobulin G4 (human-mouse monoclonal hP67.6 gamma4-chain anti-human antigen CD33), disulfide with human-mouse monoclonal hP67.6 kappa-chain, dimer, conjugate with methyl (1R, 4Z, 8S, 13E)-13-(2-((2-(((p-(3-carbamoylpropoxy)-alpha-methylbenzylidene)hydrazino)carbonyl)-1,1-dimethylethyl)dithio)ethylidene)-8-((4,6-dideoxy-4-(((2,6-dideoxy-4-S-(4-((6-deoxy-3-O-methyl-alpha-L-mannopyranosyl)oxy)-3-iodo-5,6-dimethoxy-o-toluoyl)-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-2-O-(2,4-dideoxy-4-(N-ethylacetamido)-3-O-methyl-alpha-L-threo-pentopyranosyl)-beta-D-glucopyranosyl)oxy)-1-hydroxy-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyne-10-carbamate. Molecular weight is approximately 153,000 daltons
  • Immunoglobulin G4, anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 gamma4-chain), disulfide with human-mouse monoclonal hP67.6 kappa-chain, dimer, methyl ((1R,4Z, 8S, 13E)-(8-((2-O-(4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-alpha-L-threo-pentopyranosyl)-4,6-dideoxy-4-(((2,6-dideoxy-4-S-(4-((6-deoxy-3-O-methyl-alpha-L-mannopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methylbenzoyl)-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-beta-D-glucopyranosyl)oxy)-13-(2-((3-((1-(4-(4-amino-4-oxobutoxy)phenyl)ethylidene)hydrazino)-1,1-dimethyl-3-oxopropyl)dithio)ethylidene)-1-hydroxy-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)carbamate conjugate
  • Mylotarg
  • UNII-8GZG754X6M
  • UNII-93NS566KF7
  • WAY-CMA 676
  • WAY-CMA-676

Systematic Name

  • Immunoglobulin G4 (anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 gamma4-chain)), disulfide with human-mouse monoclonal hP67 6kappa-chain, dimer, methyl ((1R,4Z,8S,13E)-8-((2-O-(4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-alpha-L-threo-pentopyranosyl)-4,6-dideoxy-4-(((2,6-dideoxy-4-S-(4-((6-deoxy-3-O-methyl-alpha-L-mannopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methylbenzoyl)-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-beta-D-glucopyranosyl)oxy)-13-(2-((3-((1-(4-(4-amino-4-oxobutoxy)phenyl)ethylidene)hydrazino)-1,1-dimethyl-3-oxopropyl)dithio)ethylidene)-1-hydroxy-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)carbamate conjugate

Registry Numbers

CAS Registry Number

  • 220578-59-6

FDA UNIIs

  • 8GZG754X6M
  • 93NS566KF7

Other Registry Number

  • 300379-19-5

System Generated Number

  • 0220578596