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Substance Name: Disopyramide phosphate [USAN:USP:BAN:JAN]
RN: 22059-60-5
UNII: N6BOM1935W
InChIKey: CGDDQFMPGMYYQP-UHFFFAOYSA-N
Note
- A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
Molecular Formulas
- C21-H29-N3-O.H3-O4-P
- C21-H29-N3-O.H3-P-O4
Molecular Weight
- 437.4738
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Cardiac Depressant (Anti-Arrhythmic)
- Drug / Therapeutic Agent
- Human Data
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Disopyramide phosphate [USAN:USP:BAN:JAN]
Synonyms
- (+-)-alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide phosphate (1:1)
- 2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, (+-)-, phosphate (1:1)
- alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide phosphate (1:1)
- alpha-(2-Diisopropylaminoethyl)-alpha-phenyl-2-pyridineacetamide phosphate
- Disopyramide phosphate
- EINECS 244-756-1
- Norpace
- Norpace CR
- NSC 756744
- Rythmodan
- SC 13957
- SC 7031 phosphate
- SC-13957
- UNII-N6BOM1935W
Systematic Names
- 2-(1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)pyridinium phosphate
- 2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, phosphate
- 2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, phosphate (1:1)
- 2-Pyridineacetamide, alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-, phosphate
Registry Numbers
CAS Registry Number
- 22059-60-5
FDA UNII
- N6BOM1935W
Related Registry Number
- 3737-09-5 (Parent)
System Generated Number
- 0022059605
Molecular Formulas
Molecular Formulas
- C21-H29-N3-O.H3-O4-P
- C21-H29-N3-O.H3-P-O4
Molecular Formula Fragments
- C21-H29-N3-O
- COMPONENT
- H3-O4-P
- H3-P-O4
Structure Descriptors
InChI
InChI=1S/C21H29N3O.H3O4P/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19;1-5(2,3)4/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25);(H3,1,2,3,4)InChIKey
CGDDQFMPGMYYQP-UHFFFAOYSA-NSmiles
CC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | LDLo | oral | 30mg/kg (30mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Medical Journal of Australia. Vol. 2, Pg. 335, 1978. |
dog | LDLo | intravenous | 30mg/kg (30mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 6, Pg. 147, 1980. |
man | LDLo | oral | 214mg/kg (214mg/kg) | Journal of Analytical Toxicology. Vol. 6, Pg. 255, 1982. | |
man | TDLo | oral | 1429ug/kg (1.429mg/kg) | ENDOCRINE: HYPOGLYCEMIA | Nippon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine. Vol. 72, Pg. 1177, 1983. |
man | TDLo | oral | 43mg/kg/5D-I (43mg/kg) | ENDOCRINE: HYPOGLYCEMIA | New York State Journal of Medicine. Vol. 83, Pg. 1057, 1983. |
man | TDLo | oral | 45mg/kg/1W-I (45mg/kg) | BEHAVIORAL: COMA | Southern Medical Journal. Vol. 76, Pg. 1453, 1983. |
man | TDLo | oral | 286mg/kg (286mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Postgraduate Medical Journal. Vol. 56, Pg. 256, 1980. |
mouse | LD50 | intraperitoneal | 190mg/kg (190mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9(Suppl, |
mouse | LD50 | intravenous | 81mg/kg (81mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9(Suppl, |
mouse | LD50 | oral | 820mg/kg (820mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9(Suppl, |
mouse | LD50 | subcutaneous | 680mg/kg (680mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9(Suppl, |
rat | LD50 | intraperitoneal | 255mg/kg (255mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9(Suppl, |
rat | LD50 | intravenous | 41mg/kg (41mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 7, Pg. 133, 1981. |
rat | LD50 | oral | 880mg/kg (880mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9(Suppl, |
rat | LD50 | subcutaneous | 1gm/kg (1000mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9(Suppl, |
women | LDLo | oral | 60mg/kg/10D-I (60mg/kg) | ENDOCRINE: HYPOGLYCEMIA | New York State Journal of Medicine. Vol. 83, Pg. 1057, 1983. |
women | LDLo | oral | 75mg/kg (75mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of the Irish Medical Association. Vol. 71, Pg. 552, 1978. |
women | TDLo | oral | 8mg/kg/1D-I (8mg/kg) | BLOOD: CHANGE IN CLOTTING FACTORS LIVER: LIVER FUNCTION TESTS IMPAIRED BLOOD: THROMBOCYTOPENIA | Southern Medical Journal. Vol. 75, Pg. 496, 1982. |
women | TDLo | oral | 20mg/kg/3D-I (20mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | American Heart Journal. Vol. 105, Pg. 870, 1983. |