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Substance Name: N-Isopropylacrylamide
RN: 2210-25-5
UNII: B7GFF17L9U
InChIKey: QNILTEGFHQSKFF-UHFFFAOYSA-N

Note

  • Can polymerize with glycidyl acrylate to form reactive water-soluble polymer that can react with the amino groups of enzymes-proteins or other ligands.

Molecular Formula

  • C6-H11-N-O

Molecular Weight

  • 113.1589
 

Classification Codes

  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
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Names and Synonyms

Name of Substance

  • N-Isopropylacrylamide

Synonyms

  • 2-Propenamide, N-(1-methylethyl)-
  • 4-04-00-00517 (Beilstein Handbook Reference)
  • Acrylamide, N-isopropyl-
  • AI3-19343
  • BRN 1744926
  • EINECS 218-638-5
  • HSDB 5868
  • Isopropyl acrylamide
  • Isopropylamid kyseliny akrylove
  • Isopropylamid kyseliny akrylove [Czech]
  • N-(1-Methylethyl)-2-propenamide
  • N-Isopropylacrylamide
  • Nipam
  • NSC 11448
  • UNII-B7GFF17L9U

Systematic Names

  • 2-Propenamide, N-(1-methylethyl)-
  • Acrylamide, N-isopropyl-
  • N-Isopropylacrylamide

Registry Numbers

CAS Registry Number

  • 2210-25-5

FDA UNII

  • B7GFF17L9U

Other Registry Numbers

  • 1254182-74-5
  • 1622299-95-9

System Generated Number

  • 0002210255

Structure Descriptors

InChI

1S/C6H11NO/c1-4-6(8)7-5(2)3/h4-5H,1H2,2-3H3,(H,7,8)

InChIKey

QNILTEGFHQSKFF-UHFFFAOYSA-N

Smiles

C(=O)(NC(C)C)C=C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 419mg/kg (419mg/kg)   Archives of Toxicology. Vol. 47, Pg. 179, 1981.
mouse LDLo intraperitoneal 500mg/kg (500mg/kg)   "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 51, 1954.
rabbit LDLo skin 1580mg/kg (1580mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: HEMORRHAGE
National Technical Information Service. Vol. OTS0545572,
rat LD50 oral 375mg/kg (375mg/kg) BLOOD: HEMORRHAGE

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
National Technical Information Service. Vol. OTS0545572,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 64 deg C   EXP
log P (octanol-water) 0.570 (none)   EST
Water Solubility 3.48E+04 mg/L 25 EST
Vapor Pressure 0.023 mm Hg 25 EST
Henry's Law Constant 2.28E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.30E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.