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Substance Name: Alclofenac [USAN:INN:BAN:JAN]
RN: 22131-79-9
UNII: M9CP5H21N8
InChIKey: ARHWPKZXBHOEEE-UHFFFAOYSA-N
Note
- An anti-inflammatory agent used in the treatment of rheumatoid arthritis; acts also as an analgesic and an antipyretic.
Molecular Formula
- C11-H11-Cl-O3
Molecular Weight
- 226.6579
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Drug / Therapeutic Agent
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
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Links to Resources
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Names and Synonyms
Name of Substance
- Alclofenac
- Alclofenac [USAN:INN:BAN:JAN]
Synonyms
- (4-(Allyloxy)-3-chlorophenyl)acetic acid
- (4-Allyloxy-3-chlorphenyl)essigsaeure
- 3-chlor-4-allyloxy-phenylacetic acid
- 3-Chloro-4-(2-propenyloxy)benzeneacetic acid
- Alclofenac
- Alclofenaco
- Alclofenaco [INN-Spanish]
- Alclofenacum
- Alclofenacum [INN-Latin]
- Alclophenac
- Allopydin
- Argun
- BRN 2116510
- Desinflam
- EINECS 244-795-4
- Kyselina 4-allyloxy-3-chlorfenyloctova
- Kyselina 4-allyloxy-3-chlorfenyloctova [Czech]
- Marvan Forte
- Medifenac
- Mervan
- MY 101
- Neosten
- Neoston
- Prinalgin
- Reufenac
- UNII-M9CP5H21N8
- W 7320
- Zumaril
Systematic Names
- Acetic acid, 4-allyloxy-3-chlorophenyl-
- Alclofenac
- Benzeneacetic acid, 3-chloro-4-(2-propenyloxy)-
Registry Numbers
CAS Registry Number
- 22131-79-9
FDA UNII
- M9CP5H21N8
System Generated Number
- 0022131799
Structure Descriptors
InChI
InChI=1S/C11H11ClO3/c1-2-5-15-10-4-3-8(6-9(10)12)7-11(13)14/h2-4,6H,1,5,7H2,(H,13,14)InChIKey
ARHWPKZXBHOEEE-UHFFFAOYSA-NSmiles
OC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 417mg/kg (417mg/kg) | Drugs in Japan Vol. -, Pg. 86, 1995. | |
mouse | LD50 | oral | 1023mg/kg (1023mg/kg) | Drugs in Japan Vol. -, Pg. 86, 1995. | |
mouse | LD50 | subcutaneous | 770mg/kg (770mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 38, 1974. |
rat | LD50 | intraperitoneal | 465mg/kg (465mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 38, 1974. |
rat | LD50 | oral | 1050mg/kg (1050mg/kg) | GASTROINTESTINAL: GASTRITIS GASTROINTESTINAL: PERITONITIS | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 618, 1970. |
rat | LD50 | subcutaneous | 750mg/kg (750mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 38, 1974. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 92.5 | deg C | EXP | |
pKa Dissociation Constant | 4.5 | (none) | EXP | |
log P (octanol-water) | 2.48 | (none) | EXP | |
Water Solubility | 600 | mg/L | 25 | EST |
Vapor Pressure | 2.12E-05 | mm Hg | 25 | EST |
Henry's Law Constant | 2.55E-09 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 3.97E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.