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Substance Name: Spectinomycin hydrochloride [USAN:USP:JAN]
RN: 22189-32-8
UNII: HWT06H303Z
InChIKey: DCHJOVNPPSBWHK-UXXUFHFZSA-N

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C14-H24-N2-O7.2Cl-H.5H2-O

Molecular Weight

  • 495.346
 
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Names and Synonyms

Name of Substance

  • Spectinomycin dihydrochloride pentahydrate
  • Spectinomycin hydrochloride [USAN:USP:JAN]

Synonyms

  • 4H-Pyrano(2,3-b)(1,4)benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, pentahydrate
  • Actinospectacin dihydrochloride pentahydrate
  • Decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-4H-pyrano(2,3-b)(1,4)benzodioxin-4-one dihydrochloride pentahydrate
  • Espectinomicina dihydrochloride pentahydrate
  • M 141
  • M-141
  • Spectam
  • Spectinomycin dihydrochloride pentahydrate
  • Spectinomycin HCl
  • Spectinomycin hydrochloride
  • Spectogard
  • Togamycin dihydrochloride pentahydrate
  • Trobicin
  • U 18,400AE
  • U-18,409AE
  • UNII-HWT06H303Z

Systematic Names

  • 4H-Pyrano(2,3-b)(1,4)benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, pentahydrate
  • Spectinomycin, dihydrochloride, pentahydrate

Registry Numbers

CAS Registry Number

  • 22189-32-8

FDA UNII

  • HWT06H303Z

Other Registry Number

  • 11034-37-0

Related Registry Number

  • 1695-77-8 (Parent)

System Generated Number

  • 0022189328

Molecular Formulas

Molecular Formula

  • C14-H24-N2-O7.2Cl-H.5H2-O

Molecular Formula Fragments

  • C14-H24-N2-O7
  • Cl-H
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1

InChIKey

DCHJOVNPPSBWHK-UXXUFHFZSA-N

Smiles

O1[C@@H]2[C@H]([C@@H](O)[C@H]([C@@H]([C@H]2O[C@@H]2O[C@H](C)CC([C@@]12O)=O)O)NC)NC.Cl.Cl.O.O.O.O.O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Japanese Journal of Antibiotics. Vol. 29, Pg. 43, 1976.
mouse LD50 intraperitoneal 2350mg/kg (2350mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Japanese Journal of Antibiotics. Vol. 29, Pg. 43, 1976.
mouse LD50 oral > 10mg/kg (10mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Japanese Journal of Antibiotics. Vol. 29, Pg. 43, 1976.
mouse LD50 subcutaneous 8400mg/kg (8400mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Japanese Journal of Antibiotics. Vol. 29, Pg. 43, 1976.
rat LD50 intramuscular > 2500mg/kg (2500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Japanese Journal of Antibiotics. Vol. 29, Pg. 43, 1976.
rat LD50 intraperitoneal 2020mg/kg (2020mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Japanese Journal of Antibiotics. Vol. 29, Pg. 43, 1976.
rat LD50 oral > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Japanese Journal of Antibiotics. Vol. 29, Pg. 43, 1976.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Japanese Journal of Antibiotics. Vol. 29, Pg. 43, 1976.