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Substance Name: Penicillamine hydrochloride
RN: 2219-30-9
UNII: 5N9JK529ZJ
InChIKey: CZDHUFYOXKHLME-DFWYDOINSA-N

Note

  • The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.

Molecular Formula

  • C5-H11-N-O2-S.Cl-H

Molecular Weight

  • 185.6738
 

Classification Code

  • Human Data
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Names and Synonyms

Name of Substance

  • Penicillamine hydrochloride

Synonyms

  • D-(-)-Penicillamine hydrochloride
  • D-Penicillamine hydrochloride
  • Distamine
  • EINECS 218-727-9
  • Penicillamine HCl
  • Penicillamine hydrochloride
  • UNII-5N9JK529ZJ
  • USAF A-1705
  • USAF EL-23

Systematic Names

  • D-Valine, 3-mercapto-, hydrochloride
  • Penicillamine hydrochloride
  • Valine, 3-mercapto-, hydrochloride, D-

Registry Numbers

CAS Registry Number

  • 2219-30-9

FDA UNII

  • 5N9JK529ZJ

System Generated Number

  • 0002219309

Molecular Formulas

Molecular Formula

  • C5-H11-N-O2-S.Cl-H

Molecular Formula Fragments

  • C5-H11-N-O2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C5H11NO2S.ClH/c1-5(2,9)3(6)4(7)8;/h3,9H,6H2,1-2H3,(H,7,8);1H/t3-;/m0./s1

InChIKey

CZDHUFYOXKHLME-DFWYDOINSA-N

Smiles

CC(C)([C@H](C(=O)O)N)S.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 5460mg/kg (5460mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" British Medical Journal. Vol. 1, Pg. 838, 1977.
man TDLo oral 6257mg/kg/2Y- (6257mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Archives of Dermatology. Vol. 121, Pg. 665, 1985.
mouse LD50 intraperitoneal 200mg/kg (200mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 intravenous 2170mg/kg (2170mg/kg)   Antibiotiki. Vol. 14, Pg. 837, 1969.
mouse LD50 oral 3670mg/kg (3670mg/kg)   Antibiotiki. Vol. 14, Pg. 837, 1969.
rat LD50 intraperitoneal 4271mg/kg (4271mg/kg)   Research Communications in Chemical Pathology and Pharmacology. Vol. 14, Pg. 153, 1976.