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Substance Name: A 25794
RN: 22198-93-2
InChIKey: APIXMWJMJACVBU-CMDGGOBGSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H21-N-O4

Molecular Weight

  • 303.356
 
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Names and Synonyms

Name of Substance

  • A 25794

Synonyms

  • Abbott-25794
  • BRN 1131015
  • PS-2747

Systematic Names

  • 2-Propenamide, N-(1,1-dimethyl-2-propynyl)-3-(3,4,5-trimethoxyphenyl)- (9CI)
  • 2-Propynylamine, 1,1-dimethyl-N-(3,4,5-trimethoxycinnamoyl)-
  • Cinnamamide, N-(1,1-dimethyl-2-propynyl)-3,4,5-trimethoxy- (8CI)
  • N-(1,1-Dimethyl-2-propynyl)-3,4,5-trimethoxycinnamamide

Registry Numbers

CAS Registry Number

  • 22198-93-2

System Generated Number

  • 0022198932

Structure Descriptors

InChI

1S/C17H21NO4/c1-7-17(2,3)18-15(19)9-8-12-10-13(20-4)16(22-6)14(11-12)21-5/h1,8-11H,2-6H3,(H,18,19)/b9-8+

InChIKey

APIXMWJMJACVBU-CMDGGOBGSA-N

Smiles

c1(c(c(cc(c1)\C=C\C(NC(C#C)(C)C)=O)OC)OC)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 499mg/kg (499mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 195, Pg. 330, 1972.
mouse LD50 oral 1109mg/kg (1109mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 195, Pg. 330, 1972.
rat LD50 intraperitoneal 352mg/kg (352mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 195, Pg. 330, 1972.
rat LD50 oral 570mg/kg (570mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: SLEEP
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 195, Pg. 330, 1972.