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Substance Name: Pyrantel pamoate [USAN:USP:JAN]
RN: 22204-24-6
UNII: 81BK194Z5M
InChIKey: AQXXZDYPVDOQEE-MXDQRGINSA-N

Note

  • Broad spectrum antinematodal anthelmintic used also in veterinary medicine.

Molecular Formulas

  • C11-H14-N2-S.C23-H16-O6
  • C23-H16-O6.C11-H14-N2-S

Molecular Weight

  • 594.685
 

Classification Codes

  • Anthelmintic
  • Anthelmintics
  • Anti-Infective Agents
  • Antinematodal Agents
  • Antiparasitic Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Pyrantel pamoate
  • Pyrantel pamoate [USAN:USP:JAN]

MeSH Heading

  • Pyrantel pamoate

Synonyms

  • (E)-1,4,5,6-Tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine 4,4'-methylenebis(3-hydroxy-2-naphthoate) (1:1)
  • Antiminth
  • Combantrin
  • CP-10,423-16
  • EINECS 244-837-1
  • Embovin
  • NSC 355080
  • Pyrantel embonate
  • Pyrantel pamoate
  • Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-, (E)-, compd. with 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylic acid) (1:1)
  • Sentry hc worm X
  • Sentry hc worm X DS
  • UNII-81BK194Z5M
  • Vetscription sure shot 2X

Systematic Names

  • 2-Naphthalenecarboxylic acid, 4,4'-methylenebis(3-hydroxy-, compd. with (E)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)pyrimidine (1:1)
  • 2-Naphthalenecarboxylic acid, 4,4'-methylenebis(3-hydroxy-, compd. with 1,4,5,6-tetrahydro-1-methyl-2-((1E)-2-(2-thienyl)ethenyl)pyrimidine (1:1)
  • 2-Naphthoic acid, 4,4'-methylenebis(3-hydroxy-, compd. with (E)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine (1:1)
  • 4,4'-Methylenebis(3-hydroxy-2-naphthoic) acid, compound with (E)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine (1:1)
  • Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-, (E)-, compd. with 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylic acid) (1:1)

Mixture Names

  • Drontal
  • Drontal Plus
  • Heartgard-30 Plus

Registry Numbers

CAS Registry Number

  • 22204-24-6

FDA UNII

  • 81BK194Z5M

Other Registry Number

  • 122157-48-6

System Generated Number

  • 0022204246

Molecular Formulas

Molecular Formulas

  • C11-H14-N2-S.C23-H16-O6
  • C23-H16-O6.C11-H14-N2-S

Molecular Formula Fragments

  • C11-H14-N2-S
  • C23-H16-O6
  • COMPONENT

Structure Descriptors

InChI

1S/C23H16O6.C11H14N2S/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2,4-6,9H,3,7-8H2,1H3/b;6-5+

InChIKey

AQXXZDYPVDOQEE-MXDQRGINSA-N

Smiles

CN1CCCN=C1/C=C/c2cccs2.c1ccc2c(c1)cc(c(c2Cc3c4ccccc4cc(c3O)C(=O)O)O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 24gm/kg (24000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 305, 1971.
mouse LD50 intraperitoneal 620mg/kg (620mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 305, 1971.
mouse LDLo subcutaneous 4gm/kg (4000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 305, 1971.
rat LD oral > 24gm/kg (24000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 305, 1971.
rat LD50 intraperitoneal 535mg/kg (535mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 305, 1971.
rat LDLo subcutaneous 6600mg/kg (6600mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 305, 1971.