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Substance Name: Carbimazole [INN:BAN:DCF]
RN: 22232-54-8
UNII: 8KQ660G60G
InChIKey: CFOYWRHIYXMDOT-UHFFFAOYSA-N

Note

  • An imidazole antithyroid agent. Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity.

Molecular Formula

  • C7-H10-N2-O2-S

Molecular Weight

  • 186.234
 

Classification Codes

  • Antithyroid Agents
  • Drug / Therapeutic Agent
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Human Data
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Carbimazole
  • Carbimazole [INN:BAN:DCF]

MeSH Heading

  • Carbimazole

Synonyms

  • 1-Ethoxycarbonyl-3-methyl-2-thioimidazol
  • 1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo, ethyl ester
  • 3-Methyl-2-thioxo-4-imidazoline-1-carboxylic acid ethyl ester
  • 4-24-00-00064 (Beilstein Handbook Reference)
  • Athyromazole
  • Atirozidina
  • Basolest
  • BRN 0144339
  • Carbethoxymethimazole
  • Carbimazol
  • Carbimazol spofa
  • Carbimazol [INN-Spanish, French]
  • Carbimazole
  • Carbimazolum
  • Carbimazolum [INN-Latin]
  • Carbotiroid
  • CG1
  • EINECS 244-854-4
  • Mertiran
  • Neo-Mercazole
  • Neo-Thyreostat
  • Neo-Tireol
  • Neomercazole
  • Thyrostat
  • Tyrazol
  • UNII-8KQ660G60G

Systematic Names

  • 1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester
  • 4-Imidazoline-1-carboxylic acid, 3-methyl-2-thioxo-, ethyl ester
  • Carbimazole
  • Ethyl 3-methyl-2-thioimidazoline-1-carboxylate

Registry Numbers

CAS Registry Number

  • 22232-54-8

FDA UNII

  • 8KQ660G60G

System Generated Number

  • 0022232548

Structure Descriptors

InChI

1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3

InChIKey

CFOYWRHIYXMDOT-UHFFFAOYSA-N

Smiles

n1(c(n(C)cc1)=S)C(OCC)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 23mg/kg/5W-I (23mg/kg) LIVER: "JAUNDICE, CHOLESTATIC" Journal of the Royal Society of Medicine. Vol. 78, Pg. 75, 1985.
women TDLo oral 25mg/kg/6W-I (25mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" Archives of Internal Medicine. Vol. 145, Pg. 1513, 1985.
women TDLo oral 703mg/kg/17W- (703mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR

SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR
British Medical Journal. Vol. 309, Pg. 929, 1994.
women TDLo parenteral 1mg/kg/1D-I (1mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" New England Journal of Medicine. Vol. 309, Pg. 438, 1983.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 123.5 deg C   EXP
log P (octanol-water) 0.530 (none)   EST
Atmospheric OH Rate Constant 9.49E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.