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Substance Name: Alefacept [USAN:INN:BAN]
RN: 222535-22-0
UNII: ELK3V90G6C

Notes

  • 1-92-LFA-3 antigen/immunoglobulin G1 fusion homodimer; used to treat plaque psoriasis; a biologic response modifier.
  • Selectively targets activated memory-effector CD45RO T lymphocytes by binding to CD2. NK cells may mediate deletion of activated T cells.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Dermatologic Agents
  • Immunologic Factors
  • Treatment of Autoimmune Diseases, Including Psoriasis and Transplant Rejection
  • Treatment of Plaque Psoriasis

Names and Synonyms

Name of Substance

  • Alefacept
  • Alefacept [USAN:INN:BAN]

MeSH Heading

  • Alefacept

Synonyms

  • 1-92-Antigen LFA 3 (human) fusion protein with human immunoglobulin G 1 (hinge-CH2-CH3 gamma1-chain), dimer. Molecular weight is 36,235 to 36,837 daltons
  • 1-92-LFA-3 (antigen) (human) fusion protein with immunoglobulin G1 (human hinge-CH2-Ch3 gamma1-chain), dimer
  • Alefacept
  • Amevive
  • ASP 0485
  • BG 9273
  • BG 9712
  • BG9273
  • BG9712
  • Human LFA 3IgG fusion protein
  • LFA 3
  • LFA 3CD2
  • LFA 3TIP
  • LFA3TIP
  • UNII-ELK3V90G6C

Systematic Name

  • 1-92-LFA-3 (antigen) (human) fusion protein with immunoglobulin G1 (human hinge-CH2-Ch3 gamma1-chain), dimer

Registry Numbers

CAS Registry Number

  • 222535-22-0

FDA UNII

  • ELK3V90G6C

System Generated Number

  • 0222535220