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Substance Name: Curarine
RN: 22260-42-0
UNII: Q06KJ82A9S
InChIKey: PXXYOLIWFSWZNP-KYJUHHDHSA-P

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C38-H44-N2-O6

Molecular Weight

  • 624.774
 
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Names and Synonyms

Name of Substance

  • Curarine

Synonyms

  • (+)-2,2'-Dimethylbebeerine
  • (+)-Curarine
  • 2,2'-Dimethylbebeerinium
  • Curarine (C33 alkaloid)
  • Curarine (C38 alkaloid)
  • Curarine (C38 alkaloid), (+)-
  • EINECS 244-880-6
  • N,N'-Dimethylbebeerinium
  • Tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-, (1'alpha)-
  • UNII-Q06KJ82A9S

Systematic Names

  • 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,1,14,14-tetramethyl-, (13aS,25aS)-
  • 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,1,14,14-tetramethyl-, (13aS-(13aR*,25aR*))-
  • Bebeerinium, 2,2'-dimethyl- (8CI)
  • Curarine
  • Tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-, (1'-alpha)- (9CI)

Registry Numbers

CAS Registry Number

  • 22260-42-0

FDA UNII

  • Q06KJ82A9S

Other Registry Numbers

  • 1401-89-4
  • 24887-67-0

System Generated Number

  • 0022260420

Structure Descriptors

InChI

1S/C38H42N2O6/c1-39(2)15-13-25-20-33(43-5)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-38-36-26(21-35(44-6)37(38)42)14-16-40(3,4)30(36)18-24-9-12-31(41)32(19-24)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/p+2/t29-,30-/m0/s1

InChIKey

PXXYOLIWFSWZNP-KYJUHHDHSA-P

Smiles

c1(c(c2c3[C@@H](Cc4cc(c(O)cc4)Oc4c(cc5c(c4)[C@@H]([N+](CC5)(C)C)Cc4ccc(cc4)O2)OC)[N+](C)(C)CCc3c1)O)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 340ug/kg (0.34mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog LDLo subcutaneous 340ug/kg (0.34mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
frog LDLo subcutaneous 16800ug/kg (16.8mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
frog LDLo unreported 8400ug/kg (8.4mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 637, 1948.
guinea pig LDLo subcutaneous 90ug/kg (0.09mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
mouse LDLo subcutaneous 380ug/kg (0.38mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
pigeon LDLo intramuscular 618ug/kg (0.618mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
pigeon LDLo subcutaneous 618ug/kg (0.618mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit LDLo intravenous 80ug/kg (0.08mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rabbit LDLo oral 334mg/kg (334mg/kg)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 61, Pg. 283, 1909.
rabbit LDLo subcutaneous 340ug/kg (0.34mg/kg)   "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 633, 1948.