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Substance Name: Apazone dihydrate
RN: 22304-30-9
UNII: BF18764H96
InChIKey: LLMGYOJUHDRDFJ-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Skin / Eye Irritant

Molecular Formula

  • C16-H20-N4-O2.2H2-O

Molecular Weight

  • 336.3896
 
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Names and Synonyms

Name of Substance

  • Apazone dihydrate

Synonyms

  • 1,2-Dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine dihydrate
  • 3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine dihydrate
  • Apazone dihydrate
  • Azapropazon dihydrat
  • Azapropazon dihydrat [German]
  • MI 85
  • Prolixan
  • Prolixana
  • Rheumox
  • Tolyprin
  • UNII-BF18764H96

Systematic Name

  • 1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, dihydrate

Registry Numbers

CAS Registry Number

  • 22304-30-9

FDA UNII

  • BF18764H96

Related Registry Number

  • 13539-59-8 (Parent)

System Generated Number

  • 0022304309

Molecular Formulas

Molecular Formula

  • C16-H20-N4-O2.2H2-O

Molecular Formula Fragments

  • C16-H20-N4-O2
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

1S/C16H20N4O2.2H2O/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22;;/h7-9,11H,5-6H2,1-4H3;2*1H2

InChIKey

LLMGYOJUHDRDFJ-UHFFFAOYSA-N

Smiles

CCCC1C(=O)N2c3cc(ccc3N=C(N2C1=O)N(C)C)C.O.O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1107mg/kg (1107mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 19, Pg. 242, 1972.
mouse LD50 intravenous 750mg/kg (750mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 36, 1969.
mouse LD50 oral 1400mg/kg (1400mg/kg)   Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976.
mouse LD50 subcutaneous 1190mg/kg (1190mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 19, Pg. 242, 1972.
rat LD50 intraperitoneal 1033mg/kg (1033mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 169, 1969.
rat LD50 intravenous 710mg/kg (710mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 36, 1969.
rat LD50 oral 1800mg/kg (1800mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 36, 1969.
rat LD50 subcutaneous 1101mg/kg (1101mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 19, Pg. 242, 1972.