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Substance Name: Clobazam [USAN:INN:BAN]
RN: 22316-47-8
UNII: 2MRO291B4U
InChIKey: CXOXHMZGEKVPMT-UHFFFAOYSA-N
Note
- A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY.
Molecular Formula
- C16-H13-Cl-N2-O2
Molecular Weight
- 300.7437
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Anti-Anxiety Agents
- Anticonvulsants
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- GABA Agents
- GABA Agonists
- GABA-A Receptor Agonists
- Human Data
- Neurotransmitter Agents
- Psychotropic Drugs
- Reproductive Effect
- Tranquilizer (Minor)
- Tranquilizing Agents
Superlist Classification Code
- DEA Schedule IV
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Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Clobazam
- Clobazam [USAN:INN:BAN]
MeSH Heading
- Clobazam
Synonyms
- 1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
- 5-24-08-00034 (Beilstein Handbook Reference)
- 7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
- BRN 0758410
- Caastilium
- CCRIS 7506
- Chlorepin
- Clobazam
- Clobazamum
- Clobazamum [INN-Latin]
- Clorepin
- EINECS 244-908-7
- Frisium
- H 4723
- H-4723
- HR 376
- HSDB 8343
- LM 2717
- LM-2717
- Noiafren
- NSC 336279
- Odipam
- Onfi
- RU-4723
- UNII-2MRO291B4U
- Urbadan
- Urbanil
- Urbanyl
Systematic Names
- 1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-diketo-3H-1,5-benzodiazepine
- 1H-1,5-Benzodiazepine-2,4(3H,5H)-dione, 7-chloro-1-methyl-5-phenyl-
- Clobazam
Superlist Names
- Clobazam
- DEA No. 2751
Registry Numbers
CAS Registry Number
- 22316-47-8
FDA UNII
- 2MRO291B4U
System Generated Number
- 0022316478
Structure Descriptors
InChI
InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3InChIKey
CXOXHMZGEKVPMT-UHFFFAOYSA-NSmiles
CN1C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | > 100mg/kg (100mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | British Journal of Clinical Pharmacology. Vol. 7, Pg. 33S, 1979. |
guinea pig | LD50 | oral | 109mg/kg (109mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | British Journal of Clinical Pharmacology. Vol. 7, Pg. 33S, 1979. |
man | TDLo | oral | 104mg/kg/1Y-C (104mg/kg) | BEHAVIORAL: WAKEFULNESS BEHAVIORAL: WITHDRAWAL GASTROINTESTINAL: NAUSEA OR VOMITING | British Medical Journal. Vol. 282, Pg. 1931, 1981. |
mouse | LD50 | intraperitoneal | 289mg/kg (289mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | British Journal of Clinical Pharmacology. Vol. 7, Pg. 33S, 1979. |
mouse | LD50 | oral | 580mg/kg (580mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 133, 1985. | |
mouse | LD50 | subcutaneous | 2250mg/kg (2250mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR | British Journal of Clinical Pharmacology. Vol. 7, Pg. 33S, 1979. |
rabbit | LD50 | oral | 320mg/kg (320mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR | British Journal of Clinical Pharmacology. Vol. 7, Pg. 33S, 1979. |
rat | LD50 | intraperitoneal | 740mg/kg (740mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR | British Journal of Clinical Pharmacology. Vol. 7, Pg. 33S, 1979. |
rat | LD50 | oral | 6gm/kg (6000mg/kg) | Medicamentos de Actualidad. Vol. 16, Pg. 9, 1980. | |
rat | LD50 | subcutaneous | 8700mg/kg (8700mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 663, 1983. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 2.12 | (none) | EXP | |
Water Solubility | 188 | mg/L | 25 | EST |
Vapor Pressure | 7.33E-10 | mm Hg | 25 | EST |
Henry's Law Constant | 2.91E-10 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.81E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.