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Substance Name: Sinomenine A dimethiodide
RN: 22445-73-4
InChIKey: MSXMISJYCGLIRF-PZCBAQPOSA-L

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C40-H48-N2-O6.2I

Molecular Weight

  • 906.627
 
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Names and Synonyms

Results Name

  • Sinomenine A dimethiodide

Synonyms

  • 2,2'-Dimethyltetrandrinium diiodide
  • N,N(sup 1)-Dimethylphaeanthine diiodide
  • Sinomenine A bis(methyl iodide)
  • Sinomenine A dimethiodide
  • Tetrandrine dimethiodide

Systematic Names

  • Berbamanium, 6,6',7,12-tetramethoxy-2,2,2',2'-tetramethyl-, diiodide, (1-beta)- (9CI)
  • Tetrandrinium, 2,2'-dimethyl-, diiodide

Registry Numbers

CAS Registry Number

  • 22445-73-4

Other Registry Number

  • 113979-31-0

System Generated Number

  • 0022445734

Molecular Formulas

Molecular Formula

  • C40-H48-N2-O6.2I

Molecular Formula Fragments

  • C40-H48-N2-O6
  • COMPONENT
  • I

Structure Descriptors

InChI

1S/C40H48N2O6.2HI/c1-41(2)17-15-27-22-34(44-6)36-24-30(27)31(41)19-25-9-12-29(13-10-25)47-35-21-26(11-14-33(35)43-5)20-32-38-28(16-18-42(32,3)4)23-37(45-7)39(46-8)40(38)48-36;;/h9-14,21-24,31-32H,15-20H2,1-8H3;2*1H/q+2;;/p-2/t31-,32-;;/m0../s1

InChIKey

MSXMISJYCGLIRF-PZCBAQPOSA-L

Smiles

COc1ccc2C[C@H]3c4c(c(c(cc4CC[N+]3(C)C)OC)OC)Oc3cc4[C@@H]([N+](C)(CCc4cc3OC)C)Cc3ccc(cc3)Oc1c2.[IH-].[IH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 7mg/kg (7mg/kg)   Chemical and Pharmaceutical Bulletin. Vol. 24, Pg. 2413, 1976.
mouse LD50 intravenous 2630ug/kg (2.63mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Acta Pharmaceutica Suecica. Vol. 7, Pg. 279, 1970.
mouse LD50 subcutaneous 24600ug/kg (24.6mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Acta Pharmaceutica Suecica. Vol. 7, Pg. 279, 1970.