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Substance Name: Clodronic acid disodium salt
RN: 22560-50-5
UNII: Y05R4GCQ1H
InChIKey: HJKBJIYDJLVSAO-UHFFFAOYSA-L

Note

  • A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.

Molecular Formula

  • C-H4-Cl2-O6-P2.2Na

Molecular Weight

  • 288.8548
 
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Names and Synonyms

Results Name

  • Clodronic acid disodium salt

Name of Substance

  • Clodronate disodium anhydrous

Synonyms

  • BM 06011
  • Bonefos
  • Chlodronate sodium
  • Clasteon
  • Clodron
  • Clodronate disodium
  • Clodronate sodium
  • Dichloromethane diphosphonate
  • Dichloromethylene diphosphonate, disodium salt
  • Disodium (dichloromethylene)bisphosphonate
  • Disodium (dichloromethylene)diphosphonate
  • Disodium clodronate
  • Disodium dichloromethylene diphosphonate
  • Disodium-dichloromethylene-diphosphonate
  • EINECS 245-078-9
  • Lodronate
  • Loron
  • Mebonat
  • Ossiten
  • Ostac
  • Sodium clodronate
  • UNII-Y05R4GCQ1H

Systematic Names

  • Disodium dihydrogen (dichloromethylene)diphosphonate
  • Phosphonic acid, (dichloromethylene)bis-, disodium salt
  • Phosphonic acid, (dichloromethylene)di-, disodium salt (8CI)

Registry Numbers

CAS Registry Number

  • 22560-50-5

FDA UNII

  • Y05R4GCQ1H

System Generated Number

  • 0022560505

Molecular Formulas

Molecular Formula

  • C-H4-Cl2-O6-P2.2Na

Molecular Formula Fragments

  • C-H4-Cl2-O6-P2
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

InChIKey

HJKBJIYDJLVSAO-UHFFFAOYSA-L

Smiles

C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 780mg/kg (780mg/kg)   British UK Patent Application. Vol. #2096889,
mouse LD50 intravenous 75mg/kg (75mg/kg)   British UK Patent Application. Vol. #2096889,
mouse LD50 oral > 2gm/kg (2000mg/kg)   British UK Patent Application. Vol. #2096889,