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Substance Name: Niludipine [INN:BAN]
RN: 22609-73-0
UNII: 9844OS3B0J
InChIKey: VZWXXKDFACOXNT-UHFFFAOYSA-N

Note

  • Bis(2-propoxyethyl) analog of nifedipine.

Molecular Formulas

  • C25-H34-N2-O8
  • C25-H38-N2-O8

Molecular Weight

  • 490.55
 

Classification Codes

  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Niludipin
  • Niludipine [INN:BAN]

Synonyms

  • Bay a 7168
  • BAY-a 7168
  • Bis(2-propoxyethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
  • BRN 0504197
  • EINECS 245-120-6
  • Niludipina
  • Niludipina [INN-Spanish]
  • Niludipine
  • Niludipinum
  • Niludipinum [INN-Latin]
  • Nilupidine
  • UNII-9844OS3B0J

Systematic Names

  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, bis(2-propoxyethyl) ester
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-, bis(2-propoxyethyl) ester
  • Bis(2-propoxyethyl) 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
  • Niludipine

Registry Numbers

CAS Registry Number

  • 22609-73-0

FDA UNII

  • 9844OS3B0J

System Generated Number

  • 0022609730

Structure Descriptors

InChI

1S/C25H34N2O8/c1-5-10-32-12-14-34-24(28)21-17(3)26-18(4)22(25(29)35-15-13-33-11-6-2)23(21)19-8-7-9-20(16-19)27(30)31/h7-9,16,23,26H,5-6,10-15H2,1-4H3

InChIKey

VZWXXKDFACOXNT-UHFFFAOYSA-N

Smiles

N1C(C)=C(C(=O)OCCOCCC)C(c2cc([N+]([O-])=O)ccc2)C(C(=O)OCCOCCC)=C1C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 90mg/kg (90mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 714, 1981.
mouse LD50 oral 1415mg/kg (1415mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 714, 1981.
mouse LD50 subcutaneous 642mg/kg (642mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 714, 1981.
rat LD50 intravenous 40mg/kg (40mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 714, 1981.
rat LD50 oral 1469mg/kg (1469mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 714, 1981.
rat LD50 subcutaneous 830mg/kg (830mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 714, 1981.