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Substance Name: Dexamethasone isonicotinate
RN: 2265-64-7
UNII: 8LGC0BOA71
InChIKey: BQTXJHAJMDGOFI-NJLPOHDGSA-N

Note

  • An anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause water and salt retention.

Molecular Formula

  • C28-H32-F-N-O6

Molecular Weight

  • 497.56
 

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Allergic Agents
  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Dexamethasone isonicotinate

MeSH Heading

  • Dexamethasone isonicotinate

Synonyms

  • Auxiloson
  • Auxilson
  • Auxilsone
  • Dexamethasone 21-isonicotinate
  • Dexamethasone isonicotinate
  • EINECS 218-866-5
  • HE 111
  • Pyridin-4-carbonsaeure-(dexamethason-21')-ester
  • Pyridin-4-carbonsaeure-(dexamethason-21')-ester [German]
  • Pyridine-4-carboxylic acid-(dexamethasone-21') ester
  • UNII-8LGC0BOA71
  • Voren

Systematic Names

  • Dexamethasone 21-isonicotinate
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-((4-pyridinylcarbonyl)oxy)-, (11beta,16alpha)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 21-isonicotinate

Registry Numbers

CAS Registry Number

  • 2265-64-7

FDA UNII

  • 8LGC0BOA71

Other Registry Number

  • 68402-70-0

System Generated Number

  • 0002265647

Structure Descriptors

InChI

1S/C28H32FNO6/c1-16-12-21-20-5-4-18-13-19(31)6-9-25(18,2)27(20,29)22(32)14-26(21,3)28(16,35)23(33)15-36-24(34)17-7-10-30-11-8-17/h6-11,13,16,20-22,32,35H,4-5,12,14-15H2,1-3H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1

InChIKey

BQTXJHAJMDGOFI-NJLPOHDGSA-N

Smiles

C1[C@H]2[C@H]3[C@@]([C@@]4(C(=CC(=O)C=C4)CC3)C)([C@@H](O)C[C@@]2([C@](C(COC(c2ccncc2)=O)=O)(O)[C@@H]1C)C)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 281mg/kg (281mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
mouse LD50 oral 3470mg/kg (3470mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
mouse LD50 subcutaneous 3211mg/kg (3211mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
rat LD50 intraperitoneal 313mg/kg (313mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
rat LD50 oral 3562mg/kg (3562mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
rat LD50 subcutaneous 3297mg/kg (3297mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.