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Substance Name: Proquazone [USAN:INN:BAN]
RN: 22760-18-5
UNII: 42VPJ2980S
InChIKey: JTIGKVIOEQASGT-UHFFFAOYSA-N

Note

  • Nonsteroid anti-inflammatory agent.

Molecular Formula

  • C18-H18-N2-O

Molecular Weight

  • 278.353
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Central Nervous System Agents
  • Cyclooxygenase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Proquazone
  • Proquazone [USAN:INN:BAN]

Synonyms

  • 1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone
  • 43-715
  • 5-24-04-00375 (Beilstein Handbook Reference)
  • Arthrex
  • Biarison
  • BRN 0889725
  • EINECS 245-203-7
  • Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone
  • Proquazona
  • Proquazona [INN-Spanish]
  • Proquazone
  • Proquazonum
  • Proquazonum [INN-Latin]
  • RU 43715
  • SaH 43-715
  • Sandoz 43-715
  • UNII-42VPJ2980S

Systematic Names

  • 2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-
  • 2(1H)-Quinazolinone, 7-methyl-1-(1-methylethyl)-4-phenyl-
  • Proquazone

Registry Numbers

CAS Registry Number

  • 22760-18-5

FDA UNII

  • 42VPJ2980S

System Generated Number

  • 0022760185

Structure Descriptors

InChI

1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3

InChIKey

JTIGKVIOEQASGT-UHFFFAOYSA-N

Smiles

c12c(n(c(=O)nc1c1ccccc1)C(C)C)cc(C)cc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 800mg/kg (800mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.
mouse LD50 intraperitoneal 339mg/kg (339mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: GENERAL ANESTHETIC
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 879, 1984.
mouse LD50 oral 930mg/kg (930mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.
rabbit LD50 oral 260mg/kg (260mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ANTIPSYCHOTIC
Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.
rat LD50 intraperitoneal 375mg/kg (375mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.
rat LD50 oral 759mg/kg (759mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 137.5 deg C   EXP
log P (octanol-water) 3.020 (none)   EST
Atmospheric OH Rate Constant 5.16E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.