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Substance Name: Proquazone [USAN:INN:BAN]
RN: 22760-18-5
UNII: 42VPJ2980S
InChIKey: JTIGKVIOEQASGT-UHFFFAOYSA-N

Note

  • Nonsteroid anti-inflammatory agent.

Molecular Formula

  • C18-H18-N2-O

Molecular Weight

  • 278.353
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Central Nervous System Agents
  • Cyclooxygenase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Proquazone
  • Proquazone [USAN:INN:BAN]

Synonyms

  • 1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone
  • 43-715
  • 5-24-04-00375 (Beilstein Handbook Reference)
  • Arthrex
  • Biarison
  • BRN 0889725
  • EINECS 245-203-7
  • Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone
  • Proquazona
  • Proquazona [INN-Spanish]
  • Proquazone
  • Proquazonum
  • Proquazonum [INN-Latin]
  • RU 43715
  • SaH 43-715
  • Sandoz 43-715
  • UNII-42VPJ2980S

Systematic Names

  • 2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-
  • 2(1H)-Quinazolinone, 7-methyl-1-(1-methylethyl)-4-phenyl-
  • Proquazone

Registry Numbers

CAS Registry Number

  • 22760-18-5

FDA UNII

  • 42VPJ2980S

System Generated Number

  • 0022760185

Structure Descriptors

InChI

1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3

InChIKey

JTIGKVIOEQASGT-UHFFFAOYSA-N

Smiles

c12c(n(c(=O)nc1c1ccccc1)C(C)C)cc(C)cc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 800mg/kg (800mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.
mouse LD50 intraperitoneal 339mg/kg (339mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 879, 1984.
mouse LD50 oral 930mg/kg (930mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.
rabbit LD50 oral 260mg/kg (260mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.
rat LD50 intraperitoneal 375mg/kg (375mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ANTIPSYCHOTIC
Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.
rat LD50 oral 759mg/kg (759mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Drug and Chemical Toxicology. Vol. 3, Pg. 361, 1980.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 137.5 deg C   EXP
log P (octanol-water) 3.020 (none)   EST
Atmospheric OH Rate Constant 5.16E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.