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Substance Name: Oxyclozanide [INN:BAN]
RN: 2277-92-1
UNII: 1QS9G4876X
InChIKey: JYWIYHUXVMAGLG-UHFFFAOYSA-N

Note

  • Anthelmintic used in grazing animals for fasciola and cestode infestations.

Molecular Formula

  • C13-H6-Cl5-N-O3

Molecular Weight

  • 401.4594
 

Classification Codes

  • Anthelmintics
  • Anti-Infective Agents
  • Antiparasitic Agents
  • Antiplatyhelmintic Agents
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Oxyclozanide
  • Oxyclozanide [INN:BAN]

MeSH Heading

  • Oxyclozanide

Synonyms

  • 2,2'-Dihydroxy-3,3',5,5',6-pentachlorobenzanilide
  • 2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide
  • 3,3',5,5',6-Pentachloro-2'-hydroxysalicylanilide
  • 3,3',5,5',6-Pentachloro-2,2'-dihydroxybenzanilide
  • 3,5,6,3',5'-Pentachloro-2,2'-dihydroxybenzanilide
  • BRN 2014120
  • CCRIS 5744
  • Diplin
  • EINECS 218-904-0
  • ICI 46638
  • ICI 46683
  • Oxiclozanida
  • Oxiclozanida [INN-Spanish]
  • Oxiclozanidum
  • Oxyclozanid
  • Oxyclozanide
  • Oxyclozanidum
  • Oxyclozanidum [INN-Latin]
  • Salicylanilide, 3,3',5,5',6-pentachloro-2'-hydroxy-
  • UNII-1QS9G4876X
  • Zanil
  • Zanilox

Systematic Names

  • 3,3',5,5',6-Pentachloro-2'-hydroxysalicylanilide
  • Benzamide, 2,3,5-trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxy- (9CI)
  • Benzanilide, 2,2'-dihydroxy-3,3',5,5',6-pentachloro-
  • Oxyclozanide

Registry Numbers

CAS Registry Number

  • 2277-92-1

FDA UNII

  • 1QS9G4876X

System Generated Number

  • 0002277921

Structure Descriptors

InChI

1S/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22)

InChIKey

JYWIYHUXVMAGLG-UHFFFAOYSA-N

Smiles

c1(C(Nc2c(c(cc(c2)Cl)Cl)O)=O)c(c(cc(c1Cl)Cl)Cl)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cattle LDLo oral 60mg/kg (60mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Veterinary Record. Vol. 78, Pg. 267, 1966.
domestic animals - goat/sheep LDLo intravenous 10mg/kg (10mg/kg)   Veterinary Record. Vol. 78, Pg. 267, 1966.
domestic animals - goat/sheep LDLo oral 60mg/kg (60mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: MUSCLE WEAKNESS
Veterinary Record. Vol. 78, Pg. 267, 1966.
rat LD50 oral 1gm/kg (1000mg/kg)   Nature. Vol. 210, Pg. 744, 1966.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 210 deg C   EXP
log P (octanol-water) 6.040 (none)   EST
Atmospheric OH Rate Constant 4.59E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.