|
|
Substance Name: Miconazole nitrate [USAN:USP:JAN]
RN: 22832-87-7
UNII: VW4H1CYW1K
InChIKey: MCCACAIVAXEFAL-UHFFFAOYSA-N
Note
- An imidazole antifungal agent that is used topically and by intravenous infusion.
Molecular Formula
- C18-H14-Cl4-N2-O.H-N-O3
Molecular Weight
- 479.1455
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Anti-Infective Agents
- Antifungal
- Antifungal Agents
- Drug / Therapeutic Agent
- Reproductive Effect
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Miconazole nitrate [USAN:USP:JAN]
Synonyms
- (+-)-Miconazole nitrate
- 1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole mononitrate
- 1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-, mononitrate
- Aflorix
- Albistat
- Andergin
- Brentan
- Conofite
- Crimak
- Daktarin
- Daktarin talc
- Deralbine
- Dermonistat
- EINECS 245-256-6
- Epi-Monistat
- Florid
- Gyno-Daktar
- Gyno-Daktarin
- Gyno-Monistat
- Lotrimin AF Jock-Itch Powder Aerosol
- Lotrimin AF Powder
- Lotrimin AF Powder Aerosol
- Lotrimin AF Spray Liquid
- M-Zole 3 Combination pack
- M-Zole 7 Dual pack
- Mezolitan
- Micatin
- Miconal Ecobi
- Miconazole 1
- Miconazole 3
- Miconazole 3 combination pack
- Miconazole 7
- Miconazole 7 combination pack
- Miconazole nitrate
- Miconazole nitrate combination pack
- Micotef
- Monistat
- Monistat 1 combination pack
- Monistat 3
- Monistat 3 Combination Pack
- Monistat 3 combination pack (prefilled)
- Monistat 5
- Monistat 7
- Monistat 7 combination pack
- Monistat Cream & Suppositories
- Monistat Dual-pak
- Monistat-3 Combination pack
- Monistat-Derm
- NSC 169434
- R 14,889
- R 14889
- UNII-VW4H1CYW1K
- Vusion
- Zeasorb-AF
Systematic Names
- 1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-, mononitrate
- Imidazole, 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)-, mononitrate
- Miconazole nitrate
Registry Numbers
CAS Registry Number
- 22832-87-7
FDA UNII
- VW4H1CYW1K
Other Registry Number
- 75319-48-1
Related Registry Number
- 22916-47-8 (Parent)
System Generated Number
- 0022832877
Molecular Formulas
Molecular Formula
- C18-H14-Cl4-N2-O.H-N-O3
Molecular Formula Fragments
- C18-H14-Cl4-N2-O
- COMPONENT
- H-N-O3
Structure Descriptors
InChI
InChI=1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)InChIKey
MCCACAIVAXEFAL-UHFFFAOYSA-NSmiles
O[N+](=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | > 160mg/kg (160mg/kg) | Chemotherapy Vol. 17(6), Pg. 392, 1972. | |
guinea pig | LD50 | oral | 276mg/kg (276mg/kg) | Chemotherapy Vol. 17(6), Pg. 392, 1972. | |
mouse | LD50 | intraperitoneal | 480mg/kg (480mg/kg) | Drugs in Japan Vol. 6, Pg. 809, 1982. | |
mouse | LD50 | intravenous | 28mg/kg (28mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 181, 1980. | |
mouse | LD50 | oral | 578mg/kg (578mg/kg) | BEHAVIORAL: ATAXIA GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Chemotherapy Vol. 17(6), Pg. 392, 1972. |
mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | BEHAVIORAL: ATAXIA GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 353, 1976. |
rat | LD50 | intraperitoneal | 1060mg/kg (1060mg/kg) | Drugs in Japan Vol. 6, Pg. 809, 1982. | |
rat | LD50 | intravenous | 14700ug/kg (14.7mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 181, 1980. | |
rat | LD50 | oral | 920mg/kg (920mg/kg) | Drugs in Japan Vol. 6, Pg. 809, 1982. | |
rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 353, 1976. |