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Substance Name: Brosuximide [INN]
RN: 22855-57-8
UNII: MH88D3N73W
InChIKey: UTVDIOAGFGTMTM-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C10-H8-Br-N-O2

Molecular Weight

  • 254.0822
 
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Names and Synonyms

Name of Substance

  • 3-Bromophenylsuccinimide
  • Brosuximide [INN]

Synonyms

  • 2-(m-Bromophenyl)succinimide
  • 3-(3-Bromophenyl)-2,5-pyrrolidinedione
  • 3-Bromophenylsuccinimide
  • 5-21-11-00194 (Beilstein Handbook Reference)
  • BRN 1457286
  • Brosuximida
  • Brosuximida [INN-Spanish]
  • Brosuximide
  • Brosuximidum
  • Brosuximidum [INN-Latin]
  • Imid kwasu 3-bromofenylobursztynowego
  • Imid kwasu 3-bromofenylobursztynowego [Polish]
  • Lefadol
  • m-Bromophenylsuccinimide
  • UNII-MH88D3N73W

Systematic Names

  • 2,5-Pyrrolidinedione, 3-(3-bromophenyl)- (9CI)
  • 2-(m-Bromophenyl)succinimide
  • Succinimide, 2-(m-bromophenyl)-

Registry Numbers

CAS Registry Number

  • 22855-57-8

FDA UNII

  • MH88D3N73W

System Generated Number

  • 0022855578

Structure Descriptors

InChI

1S/C10H8BrNO2/c11-7-3-1-2-6(4-7)8-5-9(13)12-10(8)14/h1-4,8H,5H2,(H,12,13,14)

InChIKey

UTVDIOAGFGTMTM-UHFFFAOYSA-N

Smiles

c1cc(cc(c1)Br)C2CC(=O)NC2=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 310mg/kg (310mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 13, Pg. 465, 1978.
mouse LD50 oral 920mg/kg (920mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 39, Pg. 475, 1982.
rat LD50 intraperitoneal 370mg/kg (370mg/kg)   Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 23, Pg. 593, 1971.
rat LD50 oral 1750mg/kg (1750mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA
Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 40, Pg. 657, 1983.