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Substance Name: Sotorasib [USAN]
RN: 2296729-00-3
UNII: 2B2VM6UC8G
InChIKey: NXQKSXLFSAEQCZ-SFHVURJKSA-N

Note

  • A KRAS(G12C) inhibitor.

Classification Code

  • Antineoplastic

Molecular Formula

  • C30-H30-F2-N6-O3

Molecular Weight

  • 560.5944
 
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Names and Synonyms

Name of Substance

  • Sotorasib
  • Sotorasib [USAN]

Synonyms

  • (1m)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(propan-2-yl)pyridin-3-yl)-4-((2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl)pyrido(2,3-d)pyrimidin-2(1H)-one
  • 2296729-00-3
  • 6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-((2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl)pyrido(2,3-d)pyrimidin-2-one
  • AMG 510
  • AMG-510
  • AMG510
  • Kras G12C inhibitor 9
  • Kras mutant-targeting AMG 510
  • Pyrido(2,3-d)pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(1-methylethyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl)-
  • Sotorasib
  • Sotorasib [INN]
  • UNII-2B2VM6UC8G
  • WHO 11370

Registry Numbers

CAS Registry Number

  • 2296729-00-3

FDA UNII

  • 2B2VM6UC8G

System Generated Number

  • 2296729003

Structure Descriptors

InChI

1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1

InChIKey

NXQKSXLFSAEQCZ-SFHVURJKSA-N

Smiles

CC(C)c1nccc(C)c1N2C(=O)N=C(N3CCN(C[C@@H]3C)C(=O)C=C)c4cc(F)c(nc24)c5c(O)cccc5F