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Substance Name: MPTP hydrochloride
RN: 23007-85-4
UNII: 5O1K9K2EZM
InChIKey: KOWJANGMTAZWDT-UHFFFAOYSA-N

Note

  • A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

Molecular Formula

  • C12-H15-N.Cl-H

Molecular Weight

  • 209.718
 

Classification Code

  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • MPTP hydrochloride

Synonyms

  • 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine hydrochloride
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
  • MPTP hydrochloride
  • N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
  • UNII-5O1K9K2EZM

Systematic Name

  • Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 23007-85-4

FDA UNII

  • 5O1K9K2EZM

System Generated Number

  • 0023007854

Molecular Formulas

Molecular Formula

  • C12-H15-N.Cl-H

Molecular Formula Fragments

  • C12-H15-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H

InChIKey

KOWJANGMTAZWDT-UHFFFAOYSA-N

Smiles

C1CC(=CC[N@@]1C)c1ccccc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 150mg/kg (150mg/kg)   Annales Pharmaceutiques Francaises. Vol. 12, Pg. 241, 1954.
mouse LD50 subcutaneous 53800ug/kg (53.8mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 247, Pg. 531, 1988.
rat LD50 intraperitoneal 72mg/kg (72mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: TREMOR
Bulletin of Experimental Biology and Medicine Vol. 105, Pg. 470, 1988.