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Substance Name: Terbutaline sulfate [USAN:USP:JAN]
RN: 23031-32-5
UNII: 576PU70Y8E
InChIKey: KFVSLSTULZVNPG-UHFFFAOYSA-N

Note

  • A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.

Molecular Formula

  • C12-H19-N-O3.1/2H2-O4-S

Molecular Weight

  • 548.65
 

Classification Codes

  • Bronchodilator
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Terbutaline sulfate [USAN:USP:JAN]

Synonyms

  • (+-)-alpha-((tert-Butylamino)methyl)-3,5-dihydroxybenzyl alcohol sulfate (2:1) (salt)
  • 1,3-Benzenediol, 5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-, sulfate (2:1) (salt)
  • 1-(3,5-Dihydroxyphenyl)-2-tert-butylaminoethanol sulphate
  • Brethaire
  • Brethine
  • Bricanyl
  • Bricanyl Turbuhaler
  • EINECS 245-386-3
  • KWD 2019
  • Terbutaline sulfate
  • Terbutaline sulphate
  • UNII-576PU70Y8E

Systematic Names

  • 1,3-Benzenediol, 5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-, sulfate (2:1) (salt)
  • Benzyl alcohol, alpha-((tert-butylamino)methyl)-3,5-dihydroxy-, sulfate (2:1)
  • Terbutaline sulphate

Registry Numbers

CAS Registry Number

  • 23031-32-5

FDA UNII

  • 576PU70Y8E

Other Registry Number

  • 98225-49-1

Related Registry Number

  • 23031-25-6 (Parent)

System Generated Number

  • 0023031325

Molecular Formulas

Molecular Formula

  • C12-H19-N-O3.1/2H2-O4-S

Molecular Formula Fragments

  • C12-H19-N-O3
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)

InChIKey

KFVSLSTULZVNPG-UHFFFAOYSA-N

Smiles

CC(C)(C)[NH2+]CC(c1cc(cc(c1)O)O)O.CC(C)(C)[NH2+]CC(c1cc(cc(c1)O)O)O.[O-]S(=O)(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 116mg/kg (116mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 757, 1972.
dog LD50 oral 1520mg/kg (1520mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 757, 1972.
mouse LD50 intraperitoneal 130mg/kg (130mg/kg)   Drugs in Japan Vol. 6, Pg. 500, 1982.
mouse LD50 intravenous 36mg/kg (36mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
mouse LD50 oral 205mg/kg (205mg/kg) AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 49, 1972.
mouse LD50 subcutaneous 260mg/kg (260mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rabbit LD50 intravenous 110mg/kg (110mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 757, 1972.
rabbit LD50 oral > 8gm/kg (8000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 757, 1972.
rat LD50 intraperitoneal 220mg/kg (220mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat LD50 intravenous 69mg/kg (69mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat LD50 oral 8700mg/kg (8700mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat LD50 subcutaneous 130mg/kg (130mg/kg)   Drugs in Japan Vol. 6, Pg. 500, 1982.
women TDLo oral 10mg/kg (10mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

BEHAVIORAL: TREMOR
Human Toxicology. Vol. 6, Pg. 525, 1987.
women TDLo subcutaneous 50ug/kg (0.05mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE New England Journal of Medicine. Vol. 296, Pg. 821, 1977.