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Substance Name: Disodium mycophenolate
RN: 23047-11-2
InChIKey: IPVKDGNBGUYLBL-HPJBNNNXSA-L

Note

  • An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)

Molecular Formula

  • C17-H18-O6.2Na

Molecular Weight

  • 364.303
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Results Name

  • Disodium mycophenolate

Synonyms

  • Disodium mycophenolate
  • Mycophenolic acid disodium salt

Systematic Names

  • 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, disodium salt
  • 4-Hexenoic acid, 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-, disodium salt

Registry Numbers

CAS Registry Number

  • 23047-11-2

System Generated Number

  • 0023047112

Molecular Formulas

Molecular Formula

  • C17-H18-O6.2Na

Molecular Formula Fragments

  • C17-H18-O6
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C17H20O6.2Na/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3;;/h4,20H,5-8H2,1-3H3,(H,18,19);;/q;2*+1/p-2/b9-4+;;

InChIKey

IPVKDGNBGUYLBL-HPJBNNNXSA-L

Smiles

[Na+].[O-]c1c2C(OCc2c(c(c1C\C=C(\CCC(=O)[O-])C)OC)C)=O.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 921mg/kg (921mg/kg)   Antimicrobial Agents and Chemotherapy Vol. -, Pg. 229, 1968.
mouse LD50 oral 791mg/kg (791mg/kg)   Antimicrobial Agents and Chemotherapy Vol. -, Pg. 229, 1968.