Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Lofepramine [INN:BAN]
RN: 23047-25-8
UNII: OCA4JT7PAW
InChIKey: SAPNXPWPAUFAJU-UHFFFAOYSA-N

Note

  • A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE.

Molecular Formula

  • C26-H27-Cl-N2-O

Molecular Weight

  • 418.9653
 

Classification Codes

  • Antidepressive Agents
  • Antidepressive Agents, Tricyclic
  • Central Nervous System Agents
  • Psychotropic Drugs
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Results Name

  • Lofepramine [INN:BAN]

Name of Substance

  • Lofepramine
  • Lofepramine [INN:BAN]

MeSH Heading

  • Lofepramine

Synonyms

  • 4'-Chlor-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)acetophenon
  • Amplit
  • DB 2182
  • EINECS 245-396-8
  • HSDB 7184
  • LEO 640
  • Lofepramina
  • Lofepramina [INN-Spanish]
  • Lofepramine
  • Lofepraminum
  • Lofepraminum [INN-Latin]
  • Lopramine
  • UNII-OCA4JT7PAW

Systematic Names

  • Acetophenone, 4'-chloro-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin5-yl)propyl)methylamino)-
  • Ethanone, 1-(4-chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)-
  • Lofepramine

Registry Numbers

CAS Registry Number

  • 23047-25-8

FDA UNII

  • OCA4JT7PAW

Related Registry Number

  • 26786-32-3 (hydrochloride)

System Generated Number

  • 0023047258

Structure Descriptors

InChI

1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3

InChIKey

SAPNXPWPAUFAJU-UHFFFAOYSA-N

Smiles

CN(CCCN1c2ccccc2CCc3c1cccc3)CC(=O)c4ccc(cc4)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo oral 70mg/kg (70mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
Medical Toxicology. Vol. 1, Pg. 411, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 105 deg C   EXP
log P (octanol-water) 7.260 (none)   EST
Atmospheric OH Rate Constant 2.99E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.