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Substance Name: Xylazine hydrochloride [USAN:USP]
RN: 23076-35-9
UNII: NGC3S0882S
InChIKey: QYEFBJRXKKSABU-UHFFFAOYSA-N

Note

  • An adrenergic alpha-agonist used as a sedative, analgesic, and muscle relaxant in veterinary medicine.

Molecular Formula

  • C12-H16-N2-S.Cl-H

Molecular Weight

  • 256.799
 

Classification Codes

  • Analgesic
  • Drug / Therapeutic Agent
  • Human Data
  • Relaxant (Muscle, Veterinary)
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Names and Synonyms

Name of Substance

  • Xylazine hydrochloride
  • Xylazine hydrochloride [USAN:USP]

Synonyms

  • 2-(2,6-Dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazine hydrochloride
  • 5,6-Dihydro-2-(2,6-xylidino)-4H-1,3-thiazine hydrochloride
  • 5,6-Dihydro-2-(2,6-xylidino)-4H-1,3-thiazine monohydrochloride
  • Anased
  • BAY 1470 hydrochloride
  • Bay Va 1470
  • BAY-VA 1470
  • CCRIS 8685
  • Celactal
  • EINECS 245-417-0
  • Rompun
  • Tranquived
  • UNII-NGC3S0882S
  • Xylamed
  • Xylazine chloride
  • Xylazine HCl
  • Xylazine hydrochloride

Systematic Names

  • 4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-, monohydrochloride
  • 4H-1,3-Thiazine, 5,6-dihydro-2-(2,6-xylidino)-, monohydrochloride
  • 5,6-Dihydro-2-(2,6-xylidino)-4H-1,3-thiazine monohydrochloride

Registry Numbers

CAS Registry Number

  • 23076-35-9

FDA UNII

  • NGC3S0882S

Related Registry Number

  • 7361-61-7 (Parent)

System Generated Number

  • 0023076359

Molecular Formulas

Molecular Formula

  • C12-H16-N2-S.Cl-H

Molecular Formula Fragments

  • C12-H16-N2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H

InChIKey

QYEFBJRXKKSABU-UHFFFAOYSA-N

Smiles

c1(C)c(NC=2SCCCN2)c(ccc1)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular 47mg/kg (47mg/kg)   Clinical Toxicology. Vol. 15, Pg. 281, 1979.
guinea pig LD50 intramuscular 10mg/kg (10mg/kg)   Veterinary and Human Toxicology. Vol. 24, Pg. 410, 1982.
man TDLo intramuscular 14mg/kg (14mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
Clinical Toxicology. Vol. 15, Pg. 281, 1979.
mouse LD50 intramuscular 109mg/kg (109mg/kg)   Zhongguo Yaolixue Yu Dulixue Zazhi. Vol. 9, Pg. 96, 1995.
mouse TDLo subcutaneous 29uL/kg (0.029mL/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Postgraduate Medical Journal. Vol. 66, Pg. 244, 1990.
rat LDLo oral 150mg/kg (150mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BLOOD: OTHER CHANGES
Journal of Toxicological Sciences. Vol. 25, Pg. 105, 2000.