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Substance Name: Bunitrolol hydrochloride [JAN]
RN: 23093-74-5
InChIKey: RJPWESHPIMRNNM-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C14-H20-N2-O2.Cl-H

Molecular Weight

  • 284.785
 
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Names and Synonyms

Name of Substance

  • Bunitrolol hydrochloride
  • Bunitrolol hydrochloride [JAN]

Synonyms

  • 1-t-Butylamino-3-(2-nitrilophenoxy)-2-propanol hydrochloride
  • Benzonitrile, 2-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-, hydrochloride
  • Betrilol
  • Bunitrolol HCl
  • Bunitrolol hydrochloride
  • EINECS 245-427-5
  • KO 1366
  • o-(2-Hydroxy-3-(tert-butylamino)propoxy)benzonitrile hydrochloride
  • o-(3-tert-Butylamino-2-hydroxypropoxy)benzonitrile hydrochloride
  • Stresson

Systematic Names

  • 2-(3-tert-Butylamino-2-hydroxypropoxy)benzonitrile hydrochloride
  • Benzonitrile, o-(3-(tert-butylamino)-2-hydroxypropoxy)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 23093-74-5

System Generated Number

  • 0023093745

Molecular Formulas

Molecular Formula

  • C14-H20-N2-O2.Cl-H

Molecular Formula Fragments

  • C14-H20-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C14H20N2O2.ClH/c1-14(2,3)16-9-12(17)10-18-13-7-5-4-6-11(13)8-15;/h4-7,12,16-17H,9-10H2,1-3H3;1H

InChIKey

RJPWESHPIMRNNM-UHFFFAOYSA-N

Smiles

c1(c(cccc1)C#N)OC[C@@H](C[NH2+]C(C)(C)C)O.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 36mg/kg (36mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
dog LD50 oral 490mg/kg (490mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse LD50 intraperitoneal 265mg/kg (265mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.
mouse LD50 oral 250mg/kg (250mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 25, 1981.
mouse LD50 subcutaneous 542mg/kg (542mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.
rabbit LD50 intravenous 26900ug/kg (26.9mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.
rabbit LD50 oral 430mg/kg (430mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 25, 1981.
rat LD50 intraperitoneal 222mg/kg (222mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.
rat LD50 intravenous 69mg/kg (69mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.
rat LD50 oral 639mg/kg (639mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.
rat LD50 subcutaneous 902mg/kg (902mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 457, 1975.