|
|
Substance Name: alpha-Amanitin
RN: 23109-05-9
UNII: E04K0QZ999
InChIKey: CIORWBWIBBPXCG-SXZCQOKQSA-N
Note
- A cyclic octapeptide with a thioether bridge between the cystine and tryptophan. It inhibits RNA POLYMERASE II. Poisoning may require LIVER TRANSPLANTATION.
Molecular Formula
- C39-H54-N10-O14-S
Molecular Weight
- 918.9697
Classification Codes
- Enzyme Inhibitors
- Mutation Data
- Natural Product
- Noxae
- Nucleic Acid Synthesis Inhibitors
- Poisons
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- alpha-Amanitin
MeSH Heading
- Alpha-Amanitin
Synonyms
- alpha-Amanitin
- alpha-Amanitine
- alpha-Amatoxin
- BRN 1071138
- Cyclic(L-asparaginyl-4-hydroxy-L-prolyl-(R)-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl), cyclic (4-8)-sulfide, (R)-S-oxide
- EINECS 245-432-2
- HSDB 3458
- UNII-E04K0QZ999
Systematic Names
- 9,18-(Iminoethaniminoethaniminoethaniminomethano)pyrrolo(1',2':8,9)(1,5,8,11,14)thiatetraazacyclooctadecino(18,17-b)indole, cyclic peptide deriv.
- alpha-Amanitin
- alpha-Amanitine
Registry Numbers
CAS Registry Number
- 23109-05-9
FDA UNII
- E04K0QZ999
Other Registry Numbers
- 11000-43-4
- 21150-20-9
- 21373-20-6
- 21373-21-7
- 31098-01-8
- 82346-97-2
System Generated Number
- 0023109059
Structure Descriptors
InChI
1S/C39H54N10O14S/c1-4-16(2)31-36(60)42-11-29(55)43-25-15-64(63)38-21(20-6-5-18(51)7-22(20)46-38)9-23(33(57)41-12-30(56)47-31)44-37(61)32(17(3)27(53)14-50)48-35(59)26-8-19(52)13-49(26)39(62)24(10-28(40)54)45-34(25)58/h5-7,16-17,19,23-27,31-32,46,50-53H,4,8-15H2,1-3H3,(H2,40,54)(H,41,57)(H,42,60)(H,43,55)(H,44,61)(H,45,58)(H,47,56)(H,48,59)/t16-,17-,19+,23-,24-,25-,26-,27-,31-,32-,64+/m0/s1InChIKey
CIORWBWIBBPXCG-SXZCQOKQSA-NSmiles
CC[C@H](C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 100ug/kg (0.1mg/kg) | New England Journal of Medicine. Vol. 269, Pg. 223, 1963. | |
mouse | LD50 | unreported | 300ug/kg (0.3mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 2142, 1972. |